CYLD inhibits osteoclastogenesis to ameliorate alveolar bone loss in mice with periodontitis

被引:5
|
作者
Cao, Yuxin [1 ,2 ]
Zhang, Xinming [1 ,2 ]
Hu, Meilin [1 ,2 ]
Yang, Song [3 ]
Li, Xiaoyan [1 ,2 ]
Han, Ruohui [1 ,2 ]
Zhou, Jun [3 ]
Li, Dengwen [3 ,6 ]
Liu, Dayong [1 ,2 ,4 ,5 ]
机构
[1] Tianjin Med Univ, Sch Stomatol, Dept Endodont, Tianjin, Peoples R China
[2] Tianjin Med Univ, Sch Stomatol, Lab Stem Cells Endocrine Immunol, Tianjin, Peoples R China
[3] Nankai Univ, Haihe Lab Cell Ecosyst, Dept Genet & Cell Biol, State Key Lab Med Chem Biol,Coll Life Sci, Tianjin, Peoples R China
[4] Tianjin Med Univ, Sch Stomatol, Dept Endodont, 12 Qixiangtai Rd, Tianjin 300070, Peoples R China
[5] Tianjin Med Univ, Sch Stomatol, Lab Stem Cells Endocrine Immunol, 12 Qixiangtai Rd, Tianjin 300070, Peoples R China
[6] Nankai Univ, Haihe Lab Cell Ecosyst, Dept Genet & Cell Biol, State Key Lab Med Chem Biol,Coll Life Sci, 94 Weijin Rd, Tianjin 300071, Peoples R China
基金
中国国家自然科学基金;
关键词
CYLD; knockout mouse; osteoclast; osteoporosis; periodontitis; RESORPTION;
D O I
10.1002/jcp.30990
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Periodontitis is a chronic immune inflammatory disease that can lead to the destruction and loss of the tooth-supporting apparatus. During this process, the balance between bone absorption mediated by osteoclasts and bone formation mediated by osteoblasts is damaged. Consistent with previous studies, we observed that depletion of cylindromatosis (CYLD) resulted in an osteoporotic bone phenotype. However, the effect of CYLD deficiency on periodontitis is undetermined. Here, we investigated whether CYLD affects periodontal tissue homeostasis in experimental periodontitis in Cyld knockout (KO) mice, and we explored the underlying mechanisms. Interestingly, we discovered significant alveolar bone density loss and severely reduced alveolar bone height in Cyld KO mice with experimentally induced periodontitis. We observed increased osteoclast number and activity in both the femurs and alveolar bones, accompanied by the downregulation of osteogenesis genes and upregulation of osteoclastogenesis genes of alveolar bones in ligatured Cyld KO mice. Taken together, our findings demonstrate that the deletion of CYLD in mice plays a vital role in the pathogenesis of periodontal bone loss and suggest that CYLD might exert an ameliorative effect on periodontal inflammatory responses.
引用
收藏
页码:1036 / 1045
页数:10
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