A perspective on psychedelic teratogenicity: the utility of zebrafish models

被引：3

作者：

Syed, Omer A. ^{[1
]}

Tsang, Benjamin ^{[2
]}

Petranker, Rotem ^{[3
]}

Gerlai, Robert ^{[2
,4
]}

机构：

[1] Univ Toronto Mississauga, Dept Biol, Mississauga, ON, Canada

[2] Univ Toronto, Dept Cell & Syst Biol, Toronto, ON, Canada

[3] McMaster Univ, Dept Psychol Neurosci & Behav, Hamilton, ON, Canada

[4] Univ Toronto Mississauga, Dept Psychol, Mississauga, ON, Canada

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2023年 / 44卷 / 10期

基金：

加拿大自然科学与工程研究理事会;

关键词：

EMBRYONIC ALCOHOL EXPOSURE; LYSERGIC-ACID-DIETHYLAMIDE; PREGNANT-WOMEN; MDMA ECSTASY; ADOLESCENTS; CONSUMPTION; AYAHUASCA; CHILDREN; CANNABIS; LSD;

D O I：

10.1016/j.tips.2023.08.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Psychedelic drugs have experienced an unprecedented surge in recreational use within the past few years. Among recreational users, the risks of psychedelic use by pregnant and breastfeeding women are severely understudied and there is little information on the potential teratogenic effects of these drugs. We provide an overview of the previous data on psychedelic teratogenicity from rodent studies and human surveys, discuss their limitations, and propose the utility of the zebrafish as a potential effective model for investigating psychedelic teratogenicity. Recent years have validated the use of zebrafish in the study of fetal exposure and developmental biology; we highlight these properties of the zebrafish for its suitability in psychedelic toxicity research.

引用

页码：664 / 673

页数：10

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