Association of plasma biomarkers with cognition, cognitive decline, and daily function across and within neurodegenerative diseases: Results from the Ontario Neurodegenerative Disease Research Initiative

被引：13

作者：

Sanchez, Erlan ^{[1
]}

Wilkinson, Tim ^{[1
]}

Coughlan, Gillian ^{[2
]}

Mirza, Saira ^{[1
,3
]}

Baril, Andree-Ann ^{[4
]}

Ramirez, Joel ^{[5
]}

Binns, Malcolm A. ^{[6
,7
]}

Black, Sandra E. ^{[3
,5
]}

Borrie, Michael ^{[8
,9
]}

Dilliott, Allison A. ^{[10
]}

Dixon, Roger A. ^{[11
]}

Dowlatshahi, Dar ^{[12
,13
]}

Farhan, Sali ^{[10
]}

Finger, Elizabeth ^{[8
,9
]}

Fischer, Corinne E. ^{[14
]}

Frank, Andrew ^{[15
]}

Freedman, Morris ^{[3
,6
,16
]}

Goncalves, Rafaella A. ^{[17
]}

Grimes, David A. ^{[12
,13
,18
]}

Hassan, Ayman ^{[19
]}

Hegele, Robert A. ^{[9
,20
]}

Kumar, Sanjeev ^{[21
,22
]}

Lang, Anthony E. ^{[3
,23
]}

Marras, Connie ^{[23
]}

Mclaughlin, Paula M. ^{[24
,25
]}

Orange, Joseph B. ^{[26
,27
]}

Pasternak, Stephen H. ^{[28
,29
]}

Pollock, Bruce G. ^{[21
,30
,31
]}

Rajji, Tarek K. ^{[21
,30
]}

Roberts, Angela C. ^{[26
,27
]}

Robinson, John F. ^{[9
,20
]}

Rogaeva, Ekaterina ^{[32
]}

Sahlas, Demetrios J. ^{[33
]}

Saposnik, Gustavo ^{[3
,34
]}

Strong, Michael J. ^{[9
,35
]}

Swartz, Richard H. ^{[3
,36
]}

Tang-Wai, David F. ^{[3
,37
]}

Tartaglia, Maria Carmela ^{[32
,37
]}

Troyer, Angela K. ^{[38
,39
]}

Kvartsberg, Hlin ^{[40
,41
]}

Zetterberg, Henrik ^{[40
,41
,42
,43
,44
]}

Munoz, Douglas P. ^{[17
]}

Masellis, Mario ^{[1
,3
]}

机构：

[1] Sunnybrook Res Inst, LC Campbell Cognit Neurol Res Unit, Hurvitz Brain Sci Program, Toronto, ON, Canada

[2] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA USA

[3] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada

[4] McGill Univ, Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada

[5] Sunnybrook Res Inst, Dr Sandra Black Ctr Brain Resilience & Recovery, Hurvitz Brain Sci Res Program, Toronto, ON, Canada

[6] Baycrest Hlth Sci, Rotman Res Inst, Toronto, ON, Canada

[7] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[8] Lawson Hlth Res Inst, London, ON, Canada

[9] Western Univ, Schulich Sch Med & Dent, London, ON, Canada

[10] McGill Univ, Montreal Neurol Inst Hosp, Dept Neurol & Neurosurg, Montreal, PQ, Canada

[11] Univ Alberta, Neurosci & Mental Hlth Inst, Dept Psychol, Edmonton, AB, Canada

[12] Univ Ottawa, Dept Med, Ottawa, ON, Canada

[13] Ottawa Hosp Res Inst, Ottawa, ON, Canada

[14] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr Biomed Res, Toronto, ON, Canada

[15] Univ Ottawa, Bruyere Res Inst, Ottawa, ON, Canada

[16] Mt Sinai Hosp, Dept Med, Toronto, ON, Canada

[17] Queens Univ, Ctr Neurosci Studies, Kingston, ON, Canada

[18] Univ Ottawa, Brain & Mind Res Inst, Ottawa, ON, Canada

[19] Northern Ontario Sch Med, Thunder Bay Reg Res Inst, Thunder Bay, ON, Canada

[20] Western Univ, Robarts Res Inst, London, ON, Canada

[21] Ctr Addict & Mental Hlth, Toronto, ON, Canada

[22] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[23] Toronto Western Hosp, Edmond J Safra Program Parkinsons Dis, Morton & Gloria Shulman Movement Disorders Ctr, Toronto, ON, Canada

[24] Nova Scotia Hlth, Halifax, NS, Canada

[25] Dalhousie Univ, Dept Med, Halifax, NS, Canada

[26] Western Univ, Sch Commun Sci & Disorders, London, ON, Canada

[27] Univ Western Ontario, Canadian Ctr Act & Aging, London, ON, Canada

[28] Western Univ, Dept Clin Neurol Sci, Robarts Res Inst, London, ON, Canada

[29] Western Univ, Parkwood Inst, St Josephs Hlth Care Ctr, London, ON, Canada

[30] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[31] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada

[32] Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada

[33] McMaster Univ, Hamilton, ON, Canada

[34] St Michaels Hosp, Li Ka Shing Knowledge Inst, Stroke Outcomes & Decis Neurosci Unit, Toronto, ON, Canada

[35] Canadian Inst Hlth Res, Ottawa, ON, Canada

[36] Sunnybrook Hlth Sci Ctr, Sunnybrook Res Inst, Toronto, ON, Canada

[37] Univ Hlth Network, Krembil Brain Inst, Memory Clin, Toronto, ON, Canada

[38] Univ Toronto, Dept Psychol, Toronto, ON, Canada

[39] Baycrest Hlth Sci, Neuropsychol & Cognit Hlth, Toronto, ON, Canada

[40] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Gothenburg, Sweden

[41] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[42] UCL, Dementia Res Inst, Inst Neurol, Depr Neurodegenerat Dis, Queen Sq, London, England

[43] Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China

[44] Univ Wisconsin, Wisconsin Alzheimers Dis Res Ctr, Madison, WI USA

来源：

ALZHEIMERS & DEMENTIA | 2024年 / 20卷 / 03期

基金：

瑞典研究理事会; 加拿大创新基金会; 加拿大健康研究院;

关键词：

activities of daily living; amyloid; amyloid beta; blood; blood-based; cognition; dementia; glial fibrillary acidic protein; longitudinal; neurofilament light chain; neuropsychiatric; phosphorylated tau; protein; tau; vascular; ALZHEIMERS-DISEASE; NATIONAL INSTITUTE; DIAGNOSTIC GUIDELINES; PARKINSONS-DISEASE; DEMENTIA; IMPAIRMENT; CRITERIA; RECOMMENDATIONS; WORKGROUPS;

D O I：

10.1002/alz.13560

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTIONWe investigated whether novel plasma biomarkers are associated with cognition, cognitive decline, and functional independence in activities of daily living across and within neurodegenerative diseases.METHODSGlial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), phosphorylated tau (p-tau)181 and amyloid beta (A beta)42/40 were measured using ultra-sensitive Simoa immunoassays in 44 healthy controls and 480 participants diagnosed with Alzheimer's disease/mild cognitive impairment (AD/MCI), Parkinson's disease (PD), frontotemporal dementia (FTD) spectrum disorders, or cerebrovascular disease (CVD).RESULTSGFAP, NfL, and/or p-tau181 were elevated among all diseases compared to controls, and were broadly associated with worse baseline cognitive performance, greater cognitive decline, and/or lower functional independence. While GFAP, NfL, and p-tau181 were highly predictive across diseases, p-tau181 was more specific to the AD/MCI cohort. Sparse associations were found in the FTD and CVD cohorts and for A beta 42/40.DISCUSSIONGFAP, NfL, and p-tau181 are valuable predictors of cognition and function across common neurodegenerative diseases, and may be useful in specialized clinics and clinical trials.

引用

页码：1753 / 1770

页数：18

共 14 条

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