Phase Ib multicenter study of trastuzumab deruxtecan (T-DXd) and immunotherapy with or without chemotherapy in first-line treatment of patients (pts) with advanced or metastatic nonsquamous non-small cell lung cancer (NSCLC) and HER2 overexpression (OE): DESTINY-Lung03

被引:4
|
作者
Planchard, D. [1 ]
Brahmer, J. R. [2 ]
Yang, J. C-H. [3 ]
Kim, H. R. [4 ]
Li, R. K. [5 ]
Han, J-Y. [6 ]
Cortinovis, D. L. [7 ]
Runglodvatana, Y. [8 ]
Nakajima, E. [9 ]
Ragone, A. [10 ]
Winter, M. [11 ]
Gustavson, M. [12 ]
机构
[1] Inst Gustave Roussy, Dept Med Oncol, Villejuif, France
[2] Johns Hopkins Kimmel Canc Ctr, Thorac Oncol Program, Baltimore, MD USA
[3] Natl Taiwan Univ Hosp, Dept Med Oncol, Taipei, Taiwan
[4] Yonsei Canc Ctr, Div Med Oncol, Dept Internal Med, Seoul, South Korea
[5] St Lukes Med Ctr Quezon City, Dept Med Oncol, Quezon City, Philippines
[6] Natl Canc Ctr, Ctr Lung Canc, Grad Sch Canc Sci & Policy, Goyang, South Korea
[7] Fondazione IRCCS San Gerardo dei Tintori, SC Oncol Med, Monza, Italy
[8] Navamindradhiraj Univ, Div Med Oncol, Vajira Hosp, Fac Med, Bangkok, Thailand
[9] AstraZeneca, Late Dev Oncol, R&D, Gaithersburg, MD USA
[10] AstraZe neca, Late Dev Oncol, R&D, Mississauga, ON, Canada
[11] AstraZeneca, Data Sci & Quantitat Biol, Cambridge, England
[12] AstraZeneca, Translat Med, Oncol R&D, Gaithersburg, MD USA
关键词
D O I
10.1016/j.annonc.2023.09.2538
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1507TiP
引用
收藏
页数:2
相关论文
共 50 条
  • [1] A phase Ib dose-escalation study evaluating trastuzumab deruxtecan (T-DXd) and durvalumab in combination with chemotherapy as first-line treatment in patients with advanced or metastatic nonsquamous non-small cell lung cancer (NSCLC) and HER2 overexpression (DESTINY-Lung03)
    Planchard, D.
    Yang, J. C-H.
    Brahmer, J. R.
    Ragone, A.
    Chen, J.
    Liu, F.
    Saggese, M.
    JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (04) : S798 - S798
  • [2] Trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2-mutated (HER2m) metastatic non-small cell lung cancer (NSCLC): A phase (ph) II study (DESTINY-Lung02)
    Smit, E. F. F.
    Li, B. T.
    Mazieres, J.
    Planchard, D.
    Nakagawa, K.
    Goto, K.
    Paz-Ares, L.
    Novello, S.
    Yang, J. C-H.
    Ahn, M-J.
    Liu, G.
    O'Byrne, K.
    Aregay, M.
    Shiga, R.
    Saxena, K.
    Meinhardt, G.
    Janne, P. A.
    ANNALS OF ONCOLOGY, 2021, 32 : S1032 - S1033
  • [3] Trastuzumab deruxtecan (T-DXd) in patients (Pts) with HER2-mutant metastatic non-small cell lung cancer (NSCLC): Interim results from the phase 2 DESTINY-Lung02 trial
    Goto, K.
    Sang-We, K.
    Kubo, T.
    Goto, Y.
    Ahn, M-J.
    Planchard, D.
    Kim, D-W.
    Yang, J. C-H.
    Yang, T-Y.
    Pereira, K. M. C.
    Saxena, K.
    Shiga, R.
    Cheng, Y.
    Aregay, M.
    Janne, P. A.
    ANNALS OF ONCOLOGY, 2022, 33 (07) : S1422 - S1422
  • [4] Trastuzumab deruxtecan (T-DXd; DS-8201) in combination with pembrolizumab in patients with advanced/metastatic breast or non-small cell lung cancer (NSCLC): A phase Ib, multicenter, study.
    Borghaei, Hossein
    Besse, Benjamin
    Bardia, Aditya
    Mazieres, Julien
    Popat, Sanjay
    Augustine, Bincy
    D'amelio, Anthony Michael
    Barrios, Daniel
    Rugo, Hope S.
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [5] Trastuzumab Deruxtecan Monotherapy in Pretreated HER2-overexpressing Nonsquamous Non-Small Cell Lung Cancer: DESTINY-Lung03 Part 1
    Planchard, D.
    Kim, H. R.
    Suksombooncharoen, T.
    Li, R.
    Samol, J.
    Runglodvatana, Y.
    Lee, K. -Y.
    Chang, G. -C.
    Kowalski, D.
    Han, J. -Y.
    Saw, S.
    Huang, Y.
    Sookprasert, A.
    Nakajima, E.
    Alfon, J.
    Chang, Y. -T.
    Yang, J. C. -H.
    JOURNAL OF THORACIC ONCOLOGY, 2024, 19 (10) : S46 - S47
  • [6] Open-label, randomized, multicenter, phase 3 study evaluating trastuzumab deruxtecan (T-DXd) as first-line treatment in patients with unresectable, locally advanced, or metastatic non-small cell lung cancer (NSCLC) harboring HER2 exon 19 or 20 mutations (DESTINY-Lung04).
    Li, Bob T.
    Ahn, Myung-Ju
    Goto, Koichi
    Mazieres, Julien
    Padda, Sukhmani Kaur
    William, Nassib William
    Wu, Yi-Long
    Dearden, Simon
    Ragone, Alejandra
    Viglianti, Natasha
    Gasco, Amaya
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [7] Phase 1b dose-escalation and dose-expansion study evaluating trastuzumab deruxtecan (T-DXd) in combination with durvalumab and cisplatin, carboplatin, or pemetrexed in advanced or metastatic, HER2-overexpressing, nonsquamous non-small cell lung cancer (NSCLC): DESTINY-Lung03
    Planchard, David
    Brahmer, Julie R.
    Yang, James C.
    Chen, Yuh-Min
    Lee, Kang-Yun
    Suksombooncharoen, Thatthan
    Viglianti, Natasha
    Gustavson, Mark
    Ragone, Alejandra
    Hernandez, Amaya Gasco
    CANCER RESEARCH, 2022, 82 (12)
  • [8] Primary data from DESTINY-Lung01: A phase II trial of trastuzumab deruxtecan (T-DXd) in patients (Pts) with HER2-mutated (HER2m) metastatic non-small cell lung cancer (NSCLC)
    Li, B. T.
    Smit, E. F. F.
    Goto, Y.
    Nakagawa, K.
    Udagawa, H.
    Mazieres, J.
    Nagasaka, M.
    Bazhenova, L.
    Saltos, A. N.
    Felip, E.
    Pacheco, J. M.
    Perol, M.
    Paz-Ares, L.
    Saxena, K.
    Shiga, R.
    Cheng, Y.
    Acharyya, S.
    Shahidi, J.
    Planchard, D.
    Janne, P. A.
    ANNALS OF ONCOLOGY, 2021, 32 : S1323 - S1324
  • [9] Phase II trial of trastuzumab deruxtecan (T-DXd) in patients (Pts) with HER2-mutated (HER2m) metastatic non-small cell lung cancer (NSCLC): Registrational data from DESTINY-Lung01
    Li, B. T.
    Smit, E. F.
    Goto, Y.
    Nakagawa, K.
    Goto, K.
    Mazieres, J.
    Uprety, D.
    Bazhenova, L.
    Saltos, A.
    Felip, E.
    Pacheco, J.
    Perol, M.
    Paz-Ares, L.
    Saxena, K.
    Shiga, R.
    Cheng, Y.
    Yan, Q.
    Planchard, D.
    Janne, P. A.
    ANNALS OF ONCOLOGY, 2022, 33 (07) : S995 - S996
  • [10] Trastuzumab deruxtecan (T-DXd; DS-8201) in patients with HER2-mutated metastatic non-small cell lung cancer (NSCLC): Interim results of DESTINY-Lung01.
    Smit, Egbert F.
    Nakagawa, Kazuhiko
    Nagasaka, Misako
    Felip, Enriqueta
    Goto, Yasushi
    Li, Bob T.
    Pacheco, Jose Maria
    Murakami, Haruyasu
    Barlesi, Fabrice
    Saltos, Andreas Nicholas
    Perol, Maurice
    Udagawa, Hibiki
    Saxena, Kapil
    Shiga, Ryota
    Guevara, Ferdinand M.
    Acharyya, Suddhasatta
    Shahidi, Javad
    Planchard, David
    Janne, Pasi A.
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)