Partial laryngectomy for naive pT3N0 laryngeal cancer: Systematic review on oncological outcomes

被引:5
|
作者
Campo, Flaminia [1 ,2 ]
Mazzola, Francesco [1 ]
Bianchi, Giulia [1 ]
Manciocco, Valentina [1 ]
Ralli, Massimo [2 ]
Greco, Antonio [2 ]
Sperduti, Isabella [3 ]
de Vincentiis, Marco [2 ]
Pellini, Raul [1 ]
机构
[1] Regina Elena Natl Canc Inst IRCCS, Dept Otolaryngol Head & Neck Surg, Via Elio Chianesi 53, I-00144 Rome, Italy
[2] Sapienza Univ Rome, Dept Organi di Senso, Rome, Italy
[3] Ist Fisioterap Ospitalieri IFO, Biostat Unit, IRCCS Regina Elena Natl Canc Inst, Rome, Italy
关键词
oncological outcomes; open partial laryngectomy; partial laryngectomy; pT3; total laryngectomy; SUPRACRICOID PARTIAL LARYNGECTOMY; SQUAMOUS-CELL CARCINOMA; CHEMOTHERAPY; RADIATION; SURVIVAL; SPACE;
D O I
10.1002/hed.27205
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
The first aim was to define the oncologic outcomes of open partial laryngectomy (OPL) in naive pT3 laryngeal cancer. The second aim was to analyze the outcomes after OPL versus total laryngectomy (TL). A literature search was conducted in three databases (MEDLINE, EMBASE, and Cochrane Library) until January 2022. In 805 patients treated with OPL, 5-year OS, DSS, DFS and LFS were 80.5% (95% CI 70.6-87.6), 83.4% (95% CI 75.7-89), 77.4% (95% CI 66.3-85.7) and 77.9% (95% CI 68.7-85), respectively. Three articles compared TL versus OLP: 5-year OS, DSS and DFS risk difference were 0.100 (95% CI -0.092 to 0.291), 0.067 (95% CI -0.085 to 0.220) and 0.018 (95% CI -0.164 to 0.201) respectively. OPL for selected pT3 laryngeal cancer is able to guarantee a high percentage of oncological success. Accurate patient selection is of utmost importance to differentiate advanced disease amenable to conservative surgery.
引用
收藏
页码:243 / 250
页数:8
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