Antiproliferative Activity of Gibbosic Acid H through Induction of G0/G1 Cell Cycle Arrest and Apoptosis in Human Lung Cancer Cells

被引:0
|
作者
Han, Jaeho [1 ]
Kim, Donghwa [1 ]
Park, Hyen Joo [1 ]
Park, Hee-Juhn [2 ]
Lee, Sang Kook [1 ]
机构
[1] Seoul Natl Univ, Nat Prod Res Inst, Coll Pharm, Seoul, South Korea
[2] Sangji Univ, Dept Pharmaceut Engn, Wonju, South Korea
基金
新加坡国家研究基金会;
关键词
Gibbosic acid H; Ganoderma species; Antiproliferation; Cell cycle arrest; Apoptosis; SIGNALING PATHWAY; AMPK; TRITERPENOIDS; AUTOPHAGY; GROWTH;
D O I
10.15430/JCP.2023.28.4.201
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Lung cancer is one of the most common causative cancers worldwide. Particularly, non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases. NSCLC is a serious form of lung cancer that requires prompt diagnosis, and the 5-year survival rate for patients with this disease is only 24%. Gibbosic acid H (GaH), a natural lanostanoid obtained from the Gan-oderma species (Ganodermataceae), has antiproliferative activities against colon and lung cancer cells. The aim of the present study was to evaluate the antiproliferative activity of GaH in NSCLC cells and to elucidate the underlying molecular mechanisms. GaH was found to induce G0/G1 cell cycle arrest and autophagy by activating adenosine monophosphate-activated protein kinase in A549 and H1299 cells. The induction of this cell cycle arrest was associated with the downregulation of cyclin E1 and CDK2. Additionally, the induction of autophagy by GaH was correlated with the upregulation of LC3B, beclin-1, and p53 expression. GaH also induced apoptosis by upregulating cleaved caspase-3 and Bax in the lung cancer cells. These findings suggest that GaH has a potential in the growth inhibition of human lung cancer cells.
引用
收藏
页码:201 / 211
页数:11
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