Correlations between Postoperative Changes in Nasal Microbes and Recurrence After Chronic Rhinosinusitis

The researchers aimed to analyze the correlations of nasal microbiome variations with postoperative recurrence of patients with chronic rhinosinusitis (CRS). Fifty patients receiving surgery for CRS were included. The conditions of patients with and without postoperative recurrence were evaluated by visual analogue scale and Lund -Mackay scores. The nasal bacterial composition before and after operation was analyzed by 16srDNA technology. Preoperative and postoperative operational taxonomic units showed no significant differences. At the phylum level, no significant differences were found in the dominant bacteria before and after operation. At the genus level, Moraxella and Neisseria had significantly higher proportions after operation than those before operation. Bacteroides, Pseudomonas and Streptococcus in Proteobacteria, Firmicutes and Bacteroidetes had significant differences between patients with and without postoperative recurrence. Bacteroides, Pseudomonas and Streptococcus were correlated with postoperative recurrence. Bacteroides, Pseudomonas and Streptococcus may be implicated in the poor prognosis and postoperative recurrence, as the predictors of CRS.