Establishment of a pharmacokinetics and pharmacodynamics model of Schisandra lignans against hippocampal neurotransmitters in AD rats based on microdi-alysis liquid chromatography-mass spectrometry

被引：1

作者：

Zhang, Jinpeng ^{[1
,2
]}

Cui, Xinyuan ^{[1
]}

Zhao, Shuo ^{[1
]}

Chang, Zenghui ^{[1
]}

Zhang, Junshuo ^{[1
]}

Chen, Yufeng ^{[1
]}

Liu, Jiale ^{[1
]}

Sun, Guohao ^{[1
]}

Wang, Yiyuan ^{[1
]}

Liu, Yuanyuan ^{[1
]}

机构：

[1] Shandong First Med Univ & Shandong Acad Med Sci, Coll Pharm, Dept Pharmaceut Anal, Tai An, Peoples R China

[2] Qian Xi Nan Maternal & Child Care Hosp, Xingyi, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2024年 / 15卷

基金：

中国国家自然科学基金;

关键词：

Schisandra chinensis lignans; MD-LC-TQ-MS; Alzheimer's disease; neurotransmitters; PK-PD; ALZHEIMERS-DISEASE; ACTIVATION;

D O I：

10.3389/fphar.2024.1342121

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Objective: Our previous studies substantiated that the biological activity of Schisandra chinensis lignans during the treatment of Alzheimer's disease (AD) was mediated by neurotransmitter levels, and 15 of its active components were identified. However, the pharmacokinetic and pharmacodynamic relationship of Schisandra chinensis lignans has been less studied. The objective of this study was to investigate the relationship between the pharmacokinetics and pharmacodynamics of Schisandra chinensis lignans in the treatment of AD, and to establish a pharmacokinetic-pharmacodynamic (PK-PD) model.Methods and Results: Herein, we established a microdialysis-ultra performance liquid chromatography-triple quadruple mass spectrometry (MD-LC-TQ-MS) technique that could simultaneously and continuously collect and quantitatively analyze the active compounds and neurotransmitters related to the therapeutic effects of Schisandra chinensis in awake AD rats. Eight lignans were detected in the hippocampus, and a PK-PD model was established. The fitted curves highlighted a temporal lag between the maximum drug concentration and the peak drug effect. Following treatment, the levels of four neurotransmitters tended to converge with those observed in the sham operation group.Conclusion: By establishing a comprehensive concentration-time-effect relationship for Schisandra chinensis lignans in AD treatment, our study provides novel insights into the in vivo effects of these lignans in AD rats.

引用

页数：19

共 1 条

[1] Development of a Systematic Approach to Identify Metabolites for Herbal Homologs Based on Liquid Chromatography Hybrid Ion Trap Time-of-Flight Mass Spectrometry: Gender-Related Difference in Metabolism of Schisandra Lignans in Rats
Liang, Yan
Hao, Haiping
Xie, Lin
Kang, An
Xie, Tong
Zheng, Xiao
Dai, Chen
Hao, Kun
Sheng, Longsheng
Wang, Guangji
DRUG METABOLISM AND DISPOSITION, 2010, 38 (10) : 1747 - 1759

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