The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2

被引：1
|
作者：
Hernandez, Cristian A. [1 ]
Eugenin, Eliseo A. [1 ]
机构：
[1] Univ Texas Med Branch UTMB, Dept Neurobiol, Galveston, TX 77555 USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2023年 / 73卷
关键词：
FIND-ME SIGNAL; EXTRACELLULAR ATP; T-CELLS; RELEASE; INFECTION; PLATELETS; ACTIVATION; ADENOSINE; INFLAMMATION; MECHANISMS;
D O I：
10.1016/j.coph.2023.102404
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Infectious agents such as human immune deficiency virus-1 (HIV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) use host proteins to infect, replicate, and induce inflammation within the host. A critical component of these diseases is the axis between pannexin-1 channels, extracellular ATP, and purinergic receptors. Here, we describe the potential therapeutic role of Pannexin-1/purinergic approaches to prevent or reduce the devastating consequences of these pathogens.
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页数：7
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