GENERATION OF IPSCS DERIVED FROM HIGH RISK AND LOW RISK ALZHEIMER'S DISEASE PATIENTS BASED ON POLYGENIC RISK SCORE

被引：0
|
作者：
Choi, Y. [1 ,2 ]
Lee, S. [1 ,2 ,3 ]
Son, H. [1 ,2 ,4 ]
Lee, N. [1 ,2 ,5 ]
Seo, S. [2 ,3 ,5 ,6 ]
Jang, H. [2 ,6 ]
Na, D. [1 ,2 ,6 ]
Won, H. [3 ,7 ]
Seo, J. [8 ]
Kim, H. [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Samsung Med Ctr, Cell & Gene Therapy Inst CGTI, Res Inst Future Med, Seoul, South Korea
[2] Sungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med, Suwon, South Korea
[3] Sungkyunkwan Univ, Dept Hlth Sci & Technol, SAIHST, Seoul, South Korea
[4] Sungkyunkwan Univ, Sch Med, 81 Irwon Ro, Seoul, South Korea
[5] Neuroscience Ctr, Samsung Med Ctr, 81 Irwon Ro, Seoul, South Korea
[6] Samsung Med Ctr, Alzheimers Dis Convergence Res Ctr, Seoul, South Korea
[7] Samsung Med Ctr, Samsung Genome Inst, Seoul, South Korea
[8] Daegu Gyeongbuk Inst Sci Technol, Dept Brain & Cognit Sci, Daegu, South Korea
来源：
CYTOTHERAPY | 2023年 / 25卷 / 06期
关键词：
Alzheimer's Disease; Polygenic Risk Score; Induced Pluripotent Stem Cell;
D O I：
暂无
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
1315
引用
收藏
页码：S279 / S280
页数：2
相关论文
共 50 条
  • [1] GenoRisk: A polygenic risk score for Alzheimer's disease
    Dickson, Samuel P.
    Hendrix, Suzanne B.
    Brown, Bruce L.
    Ridge, Perry G.
    Nicodemus-Johnson, Jessie
    Hardy, Marci L.
    McKeany, Allison M.
    Booth, Steven B.
    Fortna, Ryan R.
    Kauwe, John S. K.
    ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS, 2021, 7 (01)
  • [2] Polygenic Risk Score for Alzheimer's Disease in Caribbean Hispanics
    Sariya, Sanjeev
    Felsky, Daniel
    Reyes-Dumeyer, Dolly
    Lali, Ricky
    Lantigua, Rafael A.
    Vardarajan, Badri
    Jimenez-Velazquez, Ivonne Z.
    Haines, Jonathan L.
    Shellenberg, Gerard D.
    Pericak-Vance, Margaret A.
    Pare, Guillaume
    Mayeux, Richard
    Tosto, Giuseppe
    ANNALS OF NEUROLOGY, 2021, 90 (03) : 366 - 376
  • [3] Complement polygenic risk score as a predictor of Alzheimer's Disease
    Keat, Samuel
    Morales, Atahualpa Castillo
    Sims, Rebecca
    Williams, Julie
    Morgan, B. Paul
    Carpanini, Sarah
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2024, 54 : 186 - 186
  • [4] Interaction of greenness and polygenic risk score of Alzheimer's disease on risk of cognitive impairment
    Jin, Xurui
    Shu, Chang
    Zeng, Yi
    Liang, Liming
    Ji, John S.
    SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 796
  • [5] Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease
    Qiao, Min
    Lee, Annie J.
    Reyes-Dumeyer, Dolly
    Tosto, Giuseppe
    Faber, Kelley
    Goate, Alison
    Renton, Alan
    Chao, Michael
    Boeve, Brad
    Cruchaga, Carlos
    Pericak-Vance, Margaret
    Haines, Jonathan L.
    Rosenberg, Roger
    Tsuang, Debby
    Sweet, Robert A.
    Bennett, David A.
    Wilson, Robert S.
    Foroud, Tatiana
    Mayeux, Richard
    Vardarajan, Badri N.
    ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 2023, 10 (05): : 744 - 756
  • [6] Integration of risk factor polygenic risk score with disease polygenic risk score for disease prediction
    Jung, Hyein
    Jung, Hae-Un
    Baek, Eun Ju
    Kwon, Shin Young
    Kang, Ji-One
    Lim, Ji Eun
    Oh, Bermseok
    COMMUNICATIONS BIOLOGY, 2024, 7 (01)
  • [7] Integration of risk factor polygenic risk score with disease polygenic risk score for disease prediction
    Hyein Jung
    Hae-Un Jung
    Eun Ju Baek
    Shin Young Kwon
    Ji-One Kang
    Ji Eun Lim
    Bermseok Oh
    Communications Biology, 7
  • [8] Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
    Ganna Leonenko
    Emily Baker
    Joshua Stevenson-Hoare
    Annerieke Sierksma
    Mark Fiers
    Julie Williams
    Bart de Strooper
    Valentina Escott-Price
    Nature Communications, 12
  • [9] Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores
    Leonenko, Ganna
    Baker, Emily
    Stevenson-Hoare, Joshua
    Sierksma, Annerieke
    Fiers, Mark
    Williams, Julie
    de Strooper, Bart
    Escott-Price, Valentina
    NATURE COMMUNICATIONS, 2021, 12 (01)
  • [10] Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population
    Zhou, Xiaopu
    Chen, Yu
    Ip, Fanny C. F.
    Lai, Nicole C. H.
    Li, Yolanda Y. T.
    Jiang, Yuanbing
    Zhong, Huan
    Chen, Yuewen
    Zhang, Yulin
    Ma, Shuangshuang
    Lo, Ronnie M. N.
    Cheung, Kit
    Tong, Estella P. S.
    Ko, Ho
    Shoai, Maryam
    Mok, Kin Y.
    Hardy, John
    Mok, Vincent C. T.
    Kwok, Timothy C. Y.
    Fu, Amy K. Y.
    Ip, Nancy Y.
    ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING, 2020, 12 (01)
12345