Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy against SARS-CoV-2 Omicron in macaques

被引：11

作者：

Solforosi, Laura ^{[1
]}

Costes, Lea M. M. ^{[1
]}

Tolboom, Jeroen T. B. M. ^{[1
]}

McMahan, Katherine ^{[2
]}

Anioke, Tochi ^{[2
]}

Hope, David ^{[2
]}

Murdza, Tetyana ^{[2
]}

Sciacca, Michaela ^{[2
]}

Bouffard, Emily ^{[2
]}

Barrett, Julia ^{[2
]}

Wu, Cindy ^{[2
]}

Hachmann, Nicole ^{[2
]}

Miller, Jessica ^{[2
]}

Yu, Jingyou ^{[2
]}

He, Xuan ^{[2
]}

Jacob-Dolan, Catherine ^{[2
]}

Huber, Sietske K. Rosendahl ^{[1
]}

Dekking, Liesbeth ^{[1
]}

Chamanza, Ronnie ^{[3
]}

Choi, Ying ^{[1
]}

Feddes-de Boer, Karin ^{[1
]}

Barouch, Dan H. ^{[2
,4
,5
,6
]}

Schuitemaker, Hanneke ^{[1
]}

Zahn, Roland C. ^{[1
]}

Wegmann, Frank ^{[1
]}

机构：

[1] Janssen Vaccines & Prevent BV, Leiden, Netherlands

[2] Harvard Med Sch, Ctr Virol & Vaccine Res, Beth Israel Deaconess Med Ctr, Boston, MA USA

[3] Janssen Res & Dev, Nonclin Safety Toxicol Pathol, Beerse, Belgium

[4] MIT & Harvard, Ragon Inst MGH, Cambridge, MA USA

[5] Harvard Med Sch, Boston, MA USA

[6] Massachusetts Consortium Pathogen Readiness, Boston, MA USA

来源：

NATURE COMMUNICATIONS | 2023年 / 14卷 / 01期

关键词：

IMMUNOGENICITY; SAFETY;

D O I：

10.1038/s41467-023-37715-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Omicron spike (S) encoding vaccines as boosters, are a potential strategy to improve COVID-19 vaccine efficacy against Omicron. Here, macaques (mostly females) previously immunized with Ad26.COV2.S, are boosted with Ad26.COV2.S, Ad26.COV2.S.529 (encoding Omicron BA.1 S) or a 1:1 combination of both vaccines. All booster vaccinations elicit a rapid antibody titers increase against WA1/2020 and Omicron S. Omicron BA.1 and BA.2 antibody responses are most effectively boosted by vaccines including Ad26.COV2.S.529. Independent of vaccine used, mostly WA1/2020-reactive or WA1/2020-Omicron BA.1 cross-reactive B cells are detected. Ad26.COV2.S.529 containing boosters provide only slightly higher protection of the lower respiratory tract against Omicron BA.1 challenge compared with Ad26.COV2.S-only booster. Antibodies and cellular immune responses are identified as complementary correlates of protection. Overall, a booster with an Omicron-spike based vaccine provide only moderately improved immune responses and protection compared with the original Wuhan-Hu-1-spike based vaccine, which still provide robust immune responses and protection against Omicron. Variant booster vaccines are a strategy to improve protection against SARS-CoV-2. Here, the authors find that both Wuhan-Hu-1-based Ad26.COV2.S or an Omicron-adapted booster vaccine provide robust immune responses and protection against Omicron in NHP.

引用

页数：14

共 50 条

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Laura Solforosi
Lea M. M. Costes
Jeroen T. B. M. Tolboom
Katherine McMahan
Tochi Anioke
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Tetyana Murdza
Michaela Sciacca
Emily Bouffard
Julia Barrett
Cindy Wu
Nicole Hachmann
Jessica Miller
Jingyou Yu
Xuan He
Catherine Jacob-Dolan
Sietske K. Rosendahl Huber
Liesbeth Dekking
Ronnie Chamanza
Ying Choi
Karin Feddes-de Boer
Dan H. Barouch
Hanneke Schuitemaker
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Frank Wegmann
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[2] Booster vaccination with Ad26.COV2.S or an Omicron-adapted vaccine in pre-immune hamsters protects against Omicron BA.2
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[3] Booster vaccination with Ad26.COV2.S or an Omicron-adapted vaccine in pre-immune hamsters protects against Omicron BA.2
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[5] Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques
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[6] Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques
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Chung, Benjamin
Hachmann, Nicole P.
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[9] Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans
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Jacob-Dolan, Catherine
Liu, Jinyan
He, Xuan
Hope, David
Martinez, Elizabeth J.
Chen, Wei -Hung
Sciacca, Michaela
Hachmann, Nicole P.
Lifton, Michelle
Miller, Jessica
Powers, Olivia C.
Hall, Kevin
Wu, Cindy
Barrett, Julia
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