No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts

被引：1

作者：

Lund-Blix, Nicolai A. ^{[1
]}

Bjerregaard, Anne A. ^{[2
,3
]}

Tapia, German ^{[1
]}

Stordal, Ketil ^{[1
,4
,5
]}

Brantsaeter, Anne Lise ^{[1
]}

Strom, Marin ^{[2
,6
]}

Halldorsson, Thorhallur I. ^{[2
,7
]}

Granstrom, Charlotta ^{[2
]}

Svensson, Jannet ^{[8
,9
]}

Joner, Geir ^{[4
,5
]}

Skrivarhaug, Torild ^{[4
,5
]}

Njolstad, Pal R. ^{[10
,11
]}

Olsen, Sjurdur F. ^{[2
,6
,12
,13
]}

Stene, Lars C. ^{[1
]}

机构：

[1] Norwegian Inst Publ Hlth, Oslo, Norway

[2] Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark

[3] Copenhagen Univ Hosp Bispebjerg & Frederiksberg, Ctr Clin Res & Prevent, Frederiksberg, Denmark

[4] Univ Oslo, Fac Med, Div Paediat & Adolescent Med, Oslo, Norway

[5] Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway

[6] Univ Faroe Isl, Torshavn, Faroe Islands

[7] Univ Iceland, Fac Food Sci & Nutr, Reykjavik, Iceland

[8] Steno Diabet Ctr Copenhagen, Copenhagen, Denmark

[9] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

[10] Univ Bergen, Mohn Res Ctr Diabet Precis Med, Dept Clin Sci, Bergen, Norway

[11] Haukeland Hosp, Children & Youth Clin, Bergen, Norway

[12] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark

[13] Harvard TH Chan Sch Publ Hlth, Boston, MA USA

来源：

DIABETOLOGIA | 2024年 / 67卷 / 06期

基金：

欧盟地平线“2020”;

关键词：

Child health; Cohort studies; Human; Intrauterine nutrition; Maternal and child health; Nutrition; Pregnancy; Type; 1; diabetes; ISLET AUTOIMMUNITY; NORWEGIAN MOTHER; CHILD COHORT; OMEGA-3;

D O I：

10.1007/s00125-024-06125-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims/hypothesis The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids during pregnancy is associated with a lower risk of type 1 diabetes in children. Methods The Danish National Birth Cohort (DNBC) and the Norwegian Mother, Father and Child Cohort Study (MoBa) together include 153,843 mother-child pairs with prospectively collected data on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake during pregnancy from validated food frequency questionnaires. Type 1 diabetes diagnosis in children (n=634) was ascertained from national diabetes registries. Results There was no association between the sum of EPA and DHA intake during pregnancy and risk of type 1 diabetes in offspring (pooled HR per g/day of intake: 1.00, 95% CI 0.88, 1.14), with consistent results for both the MoBa and the DNBC. Robustness analyses gave very similar results. Conclusions/interpretation Initiation of a trial of EPA and DHA during pregnancy to prevent type 1 diabetes in offspring should not be prioritised.

引用

页码：1023 / 1028

页数：6

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