Palladium-Catalyzed [3+2] Annulation of ortho-Substituted Iodoarenes with Maleimides via a Consecutive Double Heck-type Strategy

被引：6

作者：

Naveen, Jakkula ^{[1
]}

Satyanarayana, Gedu ^{[1
]}

机构：

[1] Indian Inst Technol IIT Hyderabad, Dept Chem, Sangareddy 502284, Telangana, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 23期

关键词：

ONE-POT SYNTHESIS; C-H ALKYLATION; ACTIVATION; CYCLIZATION; ACCESS; ARYL; CARBOPALLADATION; HALIDES;

D O I：

10.1021/acs.joc.3c01703

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report an efficient [3 + 2] annulation of ortho-substituted iodoarenes with maleimides via a palladium-catalyzed consecutive double Heck-type strategy, leading to fused tricyclic frameworks of pharmaceutical relevance. The protocol ensued through consecutive inter- and intramolecular Heck couplings effectively. This approach was compatible with a large variety of substrates and functional groups, and it was remarkably tolerated with unprotected maleimide.

引用

页码：16229 / 16247

页数：19

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