HOXB7 induces STAT3-mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells

被引：2
|
作者：
Azuma, Kazushi [1 ]
Sakamoto, Mai [1 ,2 ]
Katayama, Shota [1 ]
Matsui, Atsuka [1 ]
Nakamichi, Kazuya [1 ]
Goshima, Naoki [3 ,4 ,5 ]
Watanabe, Shinya [6 ]
Nakayama, Jun [1 ,2 ,7 ,8 ]
Semba, Kentaro [6 ,8 ]
机构：
[1] Waseda Univ, Sch Adv Sci & Engn, Dept Life Sci & Med Biosci, Tokyo, Japan
[2] Natl Inst Adv Ind Sci & Technol, Computat Biobig Data Open Innovat Lab CBBD OIL, Tokyo, Japan
[3] Fukushima Med Univ, Translat Res Ctr, Div Transcriptome Anal, Fukushima, Japan
[4] Natl Inst Adv Ind Sci & Technol, Mol Profiling Res Ctr Drug Discovery molprof, Funct Prote Team, Tokyo, Japan
[5] Musashino Univ, Dept Human Sci, Tokyo, Japan
[6] Fukushima Med Univ, Translat Res Ctr, Fukushima, Japan
[7] Natl Canc Ctr, Lab Integrat Oncol, Tokyo, Japan
[8] Waseda Univ, Sch Adv Sci & Engn, Dept Life Sci & Med Biosci, TWIns, 2-2 Wakamatsu Cho,Shinju Ku, Tokyo 1628480, Japan
来源：
GENES TO CELLS | 2023年 / 28卷 / 04期
基金：
日本学术振兴会;
关键词：
breast cancer; ERBB2; HOXB7; metastasis; NMuMG; oncogene; BREAST-CANCER CELLS; HOXB7; PROTEIN; PROGRESSION; ACTIVATION; NETWORKS; GENES;
D O I：
10.1111/gtc.13009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The homeobox family genes are often dysregulated in various cancer types. Particularly HOXB7 amplification and overexpression correlate with poor prognosis in various cancer such as gastric, pancreatic, and lung cancers. Moreover, HOXB7 is known to contribute to cancer progression by promoting epithelial to mesenchymal transition, anticancer drug resistance, and angiogenesis. In this study, we show that HOXB7 is coamplified with ERBB2 in a subset of breast cancer patients and HOXB7 expression correlates with poor prognosis in HER2-positive breast cancer patients. This clinical observation is supported by the following results-HOXB7 overexpression in an immortalized murine mammary gland epithelial cell line NMuMG induces cellular transformation in vitro, tumorigenesis, and lung metastasis through the activation of JAK-STAT signaling.
引用
收藏
页码：277 / 287
页数：11
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