PARP1 and HPF1 team up to flag down DNA-repair machinery

被引：1
|
作者：
Rudolph, Johannes [1 ]
Luger, Karolin [1 ]
机构：
[1] Univ Colorado Boulder, Boulder, CO 80309 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2023年 / 30卷 / 05期
关键词：
ADP-RIBOSYLATION; POLY(ADP-RIBOSE); INSIGHTS;
D O I：
10.1038/s41594-023-00987-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The enzymatic activity of PARP1-which adds chains of (poly-ADP)-ribose (PAR) to proteins-initiates DNA repair by leading to more-accessible chromatin and recruitment of PAR-dependent DNA-repair proteins. New work shows that these PARP1-catalysed functions are redirected by the auxiliary factor HPF1 in cells.
引用
收藏
页码：568 / 569
页数：2
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