Effects of Combined Treatment with Sodium Dichloroacetate and Sodium Valproate on the Genes in Inflammation- and Immune-Related Pathways in T Lymphocytes from Patients with SARS-CoV-2 Infection with Pneumonia: Sex-Related Differences

被引：1

作者：

Stakisaitis, Donatas ^{[1
,2
]}

Kapocius, Linas ^{[1
]}

Tatarunas, Vacis ^{[3
]}

Gecys, Dovydas ^{[3
]}

Mickiene, Aukse ^{[4
]}

Tamosuitis, Tomas ^{[5
]}

Ugenskiene, Rasa ^{[6
]}

Vaitkevicius, Arunas ^{[7
]}

Balnyte, Ingrida ^{[1
]}

Lesauskaite, Vaiva ^{[3
]}

机构：

[1] Lithuanian Univ Hlth Sci, Med Acad, Dept Histol & Embryol, LT-44307 Kaunas, Lithuania

[2] NCI, Lab Mol Oncol, LT-08660 Vilnius, Lithuania

[3] Lithuanian Univ Hlth Sci, Inst Cardiol, Lab Mol Cardiol, LT-50161 Kaunas, Lithuania

[4] Lithuanian Univ Hlth Sci, Dept Infect Dis, LT-47116 Kaunas, Lithuania

[5] Lithuanian Univ Hlth Sci, Dept Intens Care Med, LT-50161 Kaunas, Lithuania

[6] Lithuanian Univ Hlth Sci, Dept Genet & Mol Med, LT-50161 Kaunas, Lithuania

[7] Vilnius Univ Hosp St aros Klin, Vilnius Univ Hosp Santaros Klin, Inst Clin Med, Fac Med, LT-08661 Vilnius, Lithuania

来源：

PHARMACEUTICS | 2024年 / 16卷 / 03期

关键词：

SARS-CoV-2; infection; sodium dichloroacetate and sodium valproate combination; investigational medicine; T lymphocytes; sex-related differences; inflammation; ANGIOTENSIN-CONVERTING ENZYME; HISTONE DEACETYLASE INHIBITORS; RNA EXPRESSION; CELL; COVID-19; ACID; MOUSE; APOPTOSIS; RECEPTOR; DISEASE;

D O I：

10.3390/pharmaceutics16030409

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The study presents data on the anti-inflammatory effects of a combination of sodium dichloroacetate and sodium valproate (DCA-VPA) on the expression of inflammation- and immune response-related genes in T lymphocytes of SARS-CoV-2 patients. The study aimed to assess the effects of DCA-VPA on the genes of cytokine activity, chemokine-mediated signaling, neutrophil chemotaxis, lymphocyte chemotaxis, T-cell chemotaxis, and regulation of T-cell proliferation pathways. The study included 21 patients with SARS-CoV-2 infection and pneumonia: 9 male patients with a mean age of 68.44 +/- 15.32 years and 12 female patients with a mean age of 65.42 +/- 15.74 years. They were hospitalized between December 2022 and March 2023. At the time of testing, over 90% of sequences analyzed in Lithuania were found to be of the omicron variant of SARS-CoV-2. The T lymphocytes from patients were treated with 5 mmol DCA and 2 mmol VPA for 24 h in vitro. The effect of the DCA-VPA treatment on gene expression in T lymphocytes was analyzed via gene sequencing. The study shows that DCA-VPA has significant anti-inflammatory effects and apparent sex-related differences. The effect is more potent in T cells from male patients with SARS-CoV-2 infection and pneumonia than in females.

引用

页数：25

共 2 条

[1] Effects of SARS-CoV-2 infection on male sex-related hormones in recovering patients
Xu, Hui
Wang, Zhixian
Feng, Chunxiang
Yu, Weiwei
Chen, Yuan
Zeng, Xiaoyong
Liu, Chang
ANDROLOGY, 2021, 9 (01) : 107 - 114
[2] SARS-CoV-2 Infection, Sex-Related Differences, and a Possible Personalized Treatment Approach with Valproic Acid: A Review
Stakisaitis, Donatas
Kapocius, Linas
Valanciute, Angelija
Balnyte, Ingrida
Tamosuitis, Tomas
Vaitkevicius, Arunas
Suziedelis, Kestutis
Urboniene, Daiva
Tatarunas, Vacis
Kilimaite, Evelina
Gecys, Dovydas
Lesauskaite, Vaiva
BIOMEDICINES, 2022, 10 (05)

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