LNC01296 Regulates Apoptosis Genes Birc2 and Bak1 by Targeting miRNA-29c and Participates in Neuroprotection During Cerebral Ischemia/Reperfusion Injury in Rats

被引：2

作者：

Meng, Lingjie ^{[1
]}

Qi, Yuanpu ^{[1
]}

DU, Ke ^{[1
]}

Zhang, Xiaoyu ^{[2
]}

机构：

[1] Zhengzhou Railway Vocat & Tech Coll, Rehabil & Treatment Major, Zhengzhou, Henan, Peoples R China

[2] Nanchang Univ, Fuzhou Med Coll, Fuzhou, Jiangxi, Peoples R China

来源：

TURKISH NEUROSURGERY | 2023年 / 33卷 / 01期

关键词：

LNC01296; miRNA-29c; Apoptotic gene; Cerebral ischemia-reperfusion injury; Neuroprotection; UNIQUE FEATURES; BRAIN; ISCHEMIA; PROTECTS; MODEL;

D O I：

10.5137/1019-5149.JTN.36564-21.1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

AIM: To explore the extent to which LNC01296 inhibits the miRNA-29c expansion genes Birc2 and Bak1 from causing damage induced by brain expansion and reimplantation.MATERIAL and METHODS: A total of 120 adult male experimental rats were divided to verify the effects of miRNA-29c and LNC01296 on brain expansion/reimplantation injury.RESULTS: miRNA-29c can inhibit the Birc2/Bak1 pathway and aggravate the brain expansion/reimplantation damage. LNC01296 blocks miRNA-29c from entering the brain to protect it from expansion after reimplantation.CONCLUSION: Our findings show that LINC01296 can alleviate the injury induced by cerebral ischemia and reimplantation by preventing the inhibitory effect of miR-29c on Birc2 and Bak1. Our research also provides new strategies and goals for the clinical treatment of patients with cerebral ischemia-reperfusion.

引用

页码：39 / 45

页数：7