Is orbital wall fracture associated with SARS-CoV-2 ocular surface contamination in asymptomatic COVID-19 patients?

被引:0
|
作者
Pitak-Arnnop, Poramate [1 ,2 ]
Tangmanee, Chatpong [3 ]
Meningaud, Jean-Paul [4 ]
Neff, Andreas [1 ,2 ]
机构
[1] Philipps Univ Marburg, Fac Med, Baldingerstr, D-35043 Marburg, Germany
[2] Univ Hosp Marburg, Dept Oral & Craniomaxillofacial Plast Surg, UKGM GmbH, Baldingerstr, D-35043 Marburg, Germany
[3] Chulalongkorn Univ, Dept Stat, Business Sch, Bangkok, Thailand
[4] Univ Paris Est Creteil Val Marne Paris XII, Henri Mondor Univ Hosp, AP HP, Dept Plast,Fac Med Reconstruct Esthet & Maxillofa, Creteil, France
关键词
SARS-CoV-2; Ocular surface; Contamination; Orbital fracture; Paranasal sinus; CELLULITIS;
D O I
10.1007/s10792-022-02535-8
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Objectives To assess the relationship between orbital wall fractures connecting to paranasal sinuses (OWF-PNS) and SARS-CoV-2 ocular surface contamination (SARS-CoV-2-OSC) in asymptomatic COVID-19 patients. Methods This was a prospective case-control study enrolling two asymptomatic COVID-19 patient cohorts with vs. without OWF-PNS in the case-control ratio of 1:4. All subjects were treated in a German level 1 trauma center during a one-year interval. The main predictor variable was the presence of OWF-PNS (case/control); cases with preoperative conjunctival positivity of SARS-CoV-2 were excluded to rule out the possibility of viral dissemination via the lacrimal gland and/or the nasolacrimal system. The main outcome variable was laboratory-confirmed SARS-CoV-2-OSC (yes/no). Descriptive and bivariate statistics were computed with a statistically significant P <= 0.05. Results The samples comprised 11 cases and 44 controls (overall: 27.3% females; mean age, 52.7 +/- 20.3 years [range, 19-85]). There was a significant association between OWF-PNS and SARS-CoV-2-OSC (P = 0.0001; odds ratio = 20.8; 95% confidence interval = 4.11-105.2; R-squared = 0.38; accuracy = 85.5%), regardless of orbital fracture location (orbital floor vs. medial wall versus both; P = 1.0). Conclusions Asymptomatic COVID-19 patients with OWF-PNS are associated with a considerable and almost 21-fold increase in the risk of SARS-CoV-2-OSC, in comparison with those without facial fracture. This could suggest that OWF-PNS is the viral source, requiring particular attention during manipulation of ocular/orbital tissue to prevent viral transmission.
引用
收藏
页码:1369 / 1374
页数:6
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