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- [1] Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10Scientific Reports, 11Xiang Wang论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics,Elvira Negrou论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics,Michael T. Maloney论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics,Vitaliy V. Bondar论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics,Shan V. Andrews论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics,Manuel Montalban论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics,Ceyda Llapashtica论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics,Romeo Maciuca论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics,Hoang Nguyen论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics,Hilda Solanoy论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics,Annie Arguello论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics,Laralynne Przybyla论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics,Nathan J. Moerke论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics,Sarah Huntwork-Rodriguez论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics,Anastasia G. Henry论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics,
- [2] Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10SCIENTIFIC REPORTS, 2021, 11 (01)Wang, Xiang论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USA Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USANegrou, Elvira论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USA Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USAMaloney, Michael T.论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USA Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USABondar, Vitaliy V.论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USA Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USAAndrews, Shan V.论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USA Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USAMontalban, Manuel论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USA Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USALlapashtica, Ceyda论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USA Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USAMaciuca, Romeo论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USA Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USAHoang Nguyen论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USA Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USASolanoy, Hilda论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USA Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USAArguello, Annie论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USA Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USAPrzybyla, Laralynne论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USA Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USAMoerke, Nathan J.论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USA Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USAHuntwork-Rodriguez, Sarah论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USA Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USAHenry, Anastasia G.论文数: 0 引用数: 0 h-index: 0机构: Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USA Denali Therapeutics Inc, 161 Oyster Point Blvd, South San Francisco, CA 94080 USA
- [3] LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s diseasenpj Parkinson's Disease, 8Maria Kedariti论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesEmanuele Frattini论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesPascale Baden论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesSusanna Cogo论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesLaura Civiero论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesElena Ziviani论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesGianluca Zilio论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesFederico Bertoli论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesMassimo Aureli论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesAlice Kaganovich论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesMark R. Cookson论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesLeonidas Stefanis论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesMatthew Surface论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesMichela Deleidi论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesAlessio Di Fonzo论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesRoy N. Alcalay论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesHardy Rideout论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesElisa Greggio论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic NeurosciencesNicoletta Plotegher论文数: 0 引用数: 0 h-index: 0机构: Biomedical Research Foundation of the Academy of Athens,Division of Basic Neurosciences
- [4] LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson's diseaseNPJ PARKINSONS DISEASE, 2022, 8 (01)Kedariti, Maria论文数: 0 引用数: 0 h-index: 0机构: Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, Greece Fdn IRCCS Ca Granda Osped Maggiore Policlin, Neurol Unit, Milan, Italy Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, GreeceFrattini, Emanuele论文数: 0 引用数: 0 h-index: 0机构: Univ Milan, Neurosci Sect, Dept Pathophysiol & Transplantat, Dino Ferrari Ctr, Milan, Italy Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, GreeceBaden, Pascale论文数: 0 引用数: 0 h-index: 0机构: German Ctr Neurodegenerat Dis DZNE, D-72076 Tubingen, Germany Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, GreeceCogo, Susanna论文数: 0 引用数: 0 h-index: 0机构: Univ Padua, Dept Biol, Padua, Italy Univ Reading, Sch Biol Sci, Reading, Berks, England Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, Greece论文数: 引用数: h-index:机构:Ziviani, Elena论文数: 0 引用数: 0 h-index: 0机构: Univ Padua, Dept Biol, Padua, Italy Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, Greece论文数: 引用数: h-index:机构:Bertoli, Federico论文数: 0 引用数: 0 h-index: 0机构: German Ctr Neurodegenerat Dis DZNE, D-72076 Tubingen, Germany Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, Greece论文数: 引用数: h-index:机构:Kaganovich, Alice论文数: 0 引用数: 0 h-index: 0机构: Univ Padua, Dept Biol, Padua, Italy NIA, Neurogenet Lab, Bethesda, MD USA Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, GreeceCookson, Mark R.论文数: 0 引用数: 0 h-index: 0机构: NIA, Neurogenet Lab, Bethesda, MD USA Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, GreeceStefanis, Leonidas论文数: 0 引用数: 0 h-index: 0机构: Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, Greece Univ Athens, Dept Neurol, Sch Med, Athens, Greece Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, Greece论文数: 引用数: h-index:机构:Deleidi, Michela论文数: 0 引用数: 0 h-index: 0机构: German Ctr Neurodegenerat Dis DZNE, D-72076 Tubingen, Germany Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, GreeceDi Fonzo, Alessio论文数: 0 引用数: 0 h-index: 0机构: Fdn IRCCS Ca Granda Osped Maggiore Policlin, Neurol Unit, Milan, Italy Univ Milan, Neurosci Sect, Dept Pathophysiol & Transplantat, Dino Ferrari Ctr, Milan, Italy Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, GreeceAlcalay, Roy N.论文数: 0 引用数: 0 h-index: 0机构: Columbia Univ, Irving Med Ctr, Dept Neurol, New York, NY USA Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, GreeceRideout, Hardy论文数: 0 引用数: 0 h-index: 0机构: Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, Greece Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, GreeceGreggio, Elisa论文数: 0 引用数: 0 h-index: 0机构: Univ Padua, Dept Biol, Padua, Italy Univ Padua, Ctr Neurodegenerazione CESNE, Padua, Italy Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, GreecePlotegher, Nicoletta论文数: 0 引用数: 0 h-index: 0机构: Univ Padua, Dept Biol, Padua, Italy Acad Athens, Div Basic Neurosci, Biomed Res Fdn, Athens, Greece
- [5] Characterization of LRRK2 kinase activityMOVEMENT DISORDERS, 2008, 23 (01) : S29 - S30Ryder, J. W.论文数: 0 引用数: 0 h-index: 0Anderson, B. D.论文数: 0 引用数: 0 h-index: 0Huss, K. A.论文数: 0 引用数: 0 h-index: 0Wang, X.论文数: 0 引用数: 0 h-index: 0Qian, Y. -W.论文数: 0 引用数: 0 h-index: 0Campbell, R. M.论文数: 0 引用数: 0 h-index: 0Merchant, K. M.论文数: 0 引用数: 0 h-index: 0
- [6] LRRK2 Kinase Activity is Dependent on DimerizationFASEB JOURNAL, 2010, 24Sen, Saurabh论文数: 0 引用数: 0 h-index: 0机构: Univ Alabama Birmingham, Birmingham, AL USA Univ Alabama Birmingham, Birmingham, AL USAWest, Andrew论文数: 0 引用数: 0 h-index: 0机构: Univ Alabama Birmingham, Birmingham, AL USA Univ Alabama Birmingham, Birmingham, AL USA
- [7] Assaying the Kinase Activity of LRRK2 in vitroJOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2012, (59):Lewis, Patrick A.论文数: 0 引用数: 0 h-index: 0机构: UCL Inst Neurol, Dept Mol Neurosci, London, England UCL Inst Neurol, Dept Mol Neurosci, London, England
- [8] LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP BindingPLOS ONE, 2011, 6 (08):Taymans, Jean-Marc论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, Lab Neurobiol & Gene Therapy, Louvain, Belgium Katholieke Univ Leuven, Lab Neurobiol & Gene Therapy, Louvain, BelgiumVancraenenbroeck, Renee论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, Lab Biomol Modeling, B-3001 Heverlee, Belgium Katholieke Univ Leuven, Lab Neurobiol & Gene Therapy, Louvain, BelgiumOllikainen, Petri论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, Lab Neurobiol & Gene Therapy, Louvain, Belgium Katholieke Univ Leuven, Lab Neurobiol & Gene Therapy, Louvain, BelgiumBeilina, Alexandra论文数: 0 引用数: 0 h-index: 0机构: NIA, Cell Biol & Gene Express Sect, Neurogenet Lab, NIH, Bethesda, MD 20892 USA Katholieke Univ Leuven, Lab Neurobiol & Gene Therapy, Louvain, BelgiumLobbestael, Evy论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, Lab Neurobiol & Gene Therapy, Louvain, Belgium Katholieke Univ Leuven, Lab Neurobiol & Gene Therapy, Louvain, BelgiumDe Maeyer, Marc论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, Lab Biomol Modeling, B-3001 Heverlee, Belgium Katholieke Univ Leuven, Lab Neurobiol & Gene Therapy, Louvain, BelgiumBaekelandt, Veerle论文数: 0 引用数: 0 h-index: 0机构: Katholieke Univ Leuven, Lab Neurobiol & Gene Therapy, Louvain, Belgium Katholieke Univ Leuven, Lab Neurobiol & Gene Therapy, Louvain, BelgiumCookson, Mark R.论文数: 0 引用数: 0 h-index: 0机构: NIA, Cell Biol & Gene Express Sect, Neurogenet Lab, NIH, Bethesda, MD 20892 USA Katholieke Univ Leuven, Lab Neurobiol & Gene Therapy, Louvain, Belgium
- [9] Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic MiceMOLECULAR THERAPY-NUCLEIC ACIDS, 2020, 21 : 623 - 635Korecka, Joanna A.论文数: 0 引用数: 0 h-index: 0机构: Harvard Med Sch, Neuroregenerat Res Inst, McLean Hosp, Belmont, MA 02478 USA Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA Harvard Med Sch, Neuroregenerat Res Inst, McLean Hosp, Belmont, MA 02478 USAThomas, Ria论文数: 0 引用数: 0 h-index: 0机构: Harvard Med Sch, Neuroregenerat Res Inst, McLean Hosp, Belmont, MA 02478 USA Harvard Med Sch, Neuroregenerat Res Inst, McLean Hosp, Belmont, MA 02478 USAHinrich, Anthony J.论文数: 0 引用数: 0 h-index: 0机构: Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Ctr Genet Dis, N Chicago, IL 60064 USA Harvard Med Sch, Neuroregenerat Res Inst, McLean Hosp, Belmont, MA 02478 USAMoskites, Alyssa M.论文数: 0 引用数: 0 h-index: 0机构: Harvard Med Sch, Neuroregenerat Res Inst, McLean Hosp, Belmont, MA 02478 USA Harvard Med Sch, Neuroregenerat Res Inst, McLean Hosp, Belmont, MA 02478 USAMacbain, Zach K.论文数: 0 引用数: 0 h-index: 0机构: Harvard Med Sch, Neuroregenerat Res Inst, McLean Hosp, Belmont, MA 02478 USA Harvard Med Sch, Neuroregenerat Res Inst, McLean Hosp, Belmont, MA 02478 USAHallett, Penelope J.论文数: 0 引用数: 0 h-index: 0机构: Harvard Med Sch, Neuroregenerat Res Inst, McLean Hosp, Belmont, MA 02478 USA Harvard Med Sch, Neuroregenerat Res Inst, McLean Hosp, Belmont, MA 02478 USAIsacson, Ole论文数: 0 引用数: 0 h-index: 0机构: Harvard Med Sch, Neuroregenerat Res Inst, McLean Hosp, Belmont, MA 02478 USA Harvard Med Sch, Neuroregenerat Res Inst, McLean Hosp, Belmont, MA 02478 USAHastings, Michelle L.论文数: 0 引用数: 0 h-index: 0机构: Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Ctr Genet Dis, N Chicago, IL 60064 USA Harvard Med Sch, Neuroregenerat Res Inst, McLean Hosp, Belmont, MA 02478 USA
- [10] Inhibition of LRRK2 kinase activity stimulates macroautophagyBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2013, 1833 (12): : 2900 - 2910Manzoni, Claudia论文数: 0 引用数: 0 h-index: 0机构: UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, EnglandMamais, Adamantios论文数: 0 引用数: 0 h-index: 0机构: UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England UCL Inst Neurol, Reta Lila Weston Inst, London WC1N 1PJ, England UCL Inst Neurol, Queen Sq Brain Bank, London WC1N 1PJ, England UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, EnglandDihanich, Sybille论文数: 0 引用数: 0 h-index: 0机构: UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, EnglandAbeti, Rosella论文数: 0 引用数: 0 h-index: 0机构: UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, EnglandSoutar, Marc P. M.论文数: 0 引用数: 0 h-index: 0机构: UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, EnglandPlun-Favreau, Helene论文数: 0 引用数: 0 h-index: 0机构: UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, EnglandGiunti, Paola论文数: 0 引用数: 0 h-index: 0机构: UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, EnglandTooze, Sharon A.论文数: 0 引用数: 0 h-index: 0机构: Canc Res UK London Res Inst, Lincolns Inn Fields, London WC2A 3LY, England UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, EnglandBandopadhyay, Rina论文数: 0 引用数: 0 h-index: 0机构: UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England UCL Inst Neurol, Reta Lila Weston Inst, London WC1N 1PJ, England UCL Inst Neurol, Queen Sq Brain Bank, London WC1N 1PJ, England UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, EnglandLewis, Patrick A.论文数: 0 引用数: 0 h-index: 0机构: UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England Univ Reading, Sch Pharm, Reading RG6 6AP, Berks, England UCL Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England