HPLC DETERMINATION OF BIPERIDEN IN SOLID DOSAGE FORMS

被引：0
|
作者：
Angelov, Trifon Milchev [1 ]
Krastanova, Biljana Slaveva [2 ]
Pashev, Alexandar Svilenov [1 ]
Jotova, Maya Chavdarova [1 ]
机构：
[1] Med Univ Pleven, Fac Pharm, 1 St Kliment Ohridski St, Pleven 5800, Bulgaria
[2] Tchaikapharma High Qual Med Inc, 1 GM Dimitrov Blvd, Sofia 1172, Bulgaria
来源：
COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES | 2023年 / 76卷 / 02期
关键词：
biperiden; HPLC-UV; assay; method development;
D O I：
10.7546/CRABS.2023.02.02
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A rapid, new analytical method, based on liquid chromatography with UV detection, has been developed and utilised for the determination of biperi-den hydrochloride in solid dosage forms. The chromatographic separation was performed on a conventional C18 reversed phase column with a mobile phase composed of acetonitrile-buffer mixture. Ultraviolet detection was carried out at 205 nm. A rapid extraction procedure using ultrasonic bath obtained good extraction yield values for the analyte (>= 98.4%). The method was developed specifically for routine analysis of biperiden in solid dosage forms in the appli-cable concentration range. The linearity and range of the method investigated for the assay of biperiden is between 2-6 mu g mL-1. The method is selective and sufficiently precise. Thus, the method developed is suitable for routine analysis of biperiden.
引用
收藏
页码：184 / 191
页数：8
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