Facile biosynthesis of copper oxide nanoparticles using Mangifera indica leaf extract: Characterization and bioactivities

In this study, copper oxide nanoparticles (CuONPs) were facilely synthesized via a bio-pathway with the Man-gifera indica leaf extract. The characterization results showed the development of monoclinic CuO as relatively stable nanospheres (15 - 40 nm) and also confirmed the great stability of the CuONPs. Bioactivities of CuONPs were assessed against bacteria strains and cytotoxicity. Accordingly, the CuO-2 sample well-restrained the microbe with over 60 % of inhibition at 50 mu g/mL as well as exhibited excellent cytotoxicity, especially low IC50 value towards the cancerous HepG2 (1.98 mu g/mL). The material also exhibited a negligible inhibitory against normal HEK293 cell lines, which affirms the great biocompatibility in the anticancer activity. Conclusively, green-synthesized CuONPs show good bioactivities and are highly promising for medical applications.