What is known about the effects of vitamin D in neuropsychiatric lupus?

被引：0

作者：

Karnopp, Thais Evelyn ^{[1
,2
,3
]}

Freitas, Vinicius da Silva ^{[1
,3
]}

Di Domenico, Andressa Leite ^{[1
,3
]}

Chapacais, Gustavo Flores ^{[1
,2
,3
]}

dos Santos, Natalia Garcia ^{[1
,3
,4
]}

Freitas, Eduarda Correa ^{[1
,3
]}

Gasparin, Andrese Aline ^{[3
]}

Monticielo, Odirlei Andre ^{[1
,3
]}

机构：

[1] Univ Fed Rio Grande Do Sul, Hosp Clin Porto Alegre, Ctr Pesquisas Expt, Lab Autoimmune Dis,Div Rheumatol, Rua Ramiro Barcelos 2350,Sala 12109, BR-90035003 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande Do Sul, Postgrad Program Hlth Sci, Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande Do Sul, Hosp Clin Porto Alegre, Dept Internal Med, Div Rheumatol, Porto Alegre, RS, Brazil

[4] Postgrad Program Biol Sci Pharmacol & Therapeut, Postgrad Program Biol Sci, Porto Alegre, RS, Brazil

来源：

ADVANCES IN RHEUMATOLOGY | 2024年 / 64卷 / 01期

关键词：

Systemic lupus erythematosus; Neuropsychiatric lupus; Vitamin D; Hypovitaminosis D; Vitamin D supplementation; 1,25-DIHYDROXYVITAMIN D-3; AUTOIMMUNE-DISEASES; D DEFICIENCY; D-RECEPTOR; ERYTHEMATOSUS; SYSTEM; BRAIN; PAIN; CONSEQUENCES; ASSOCIATION;

D O I：

10.1186/s42358-023-00344-w

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect several organs and systems. The central and/or peripheral nervous system can suffer from complications known as neuropsychiatric lupus (NPSLE). Studies have associated the manifestations of SLE or NPSLE with vitamin D deficiency. It has been shown that hypovitaminosis D can lead to cognition deficits and cerebral hypoperfusion in patients with NPSLE. In this review article, we will address the main features related to vitamin D supplementation or serum vitamin D levels with neuropsychiatric manifestations, either in patients or in animal models of NPSLE.

引用

页数：11

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