The predictive value of HALP score and systemic immune inflammation (SII) index in patients with asthma The role of HALP score in patients with asthma

Aim: Recent studies showed that the immune inflammatory response plays a significant role in patients with asthma. The objective of the current study is to examine whether hemoglobin, albumin, lymphocyte, and platelet (HALP) score and systemic inflammatory response index (SII) are effective in predicting asthma. Material and Methods: In this retrospective case-control study, seventy patients diagnosed with asthma and 70 healthy subjects followed in the Allergy and Immunology Clinics of Ordu University Education and Research Hospital were included. The HALP score was calculated according to the following formula: HALP score = (hemoglobin (g/L) x albumin (g/L) x lymphocytes (/L))/platelets (/L). The SII index was calculated according to this formula SII (neutrophil x platelet/lymphocyte count). Results: Neutrophil, lymphocyte, monocyte, mean platelet volume (MPV), CRP were statitically significant betweeen the groups (p<0.05, Table 2). However, there was no statistically significant difference between white blood cells and platelets. A statistically significant difference was found between SII, HALP score neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) indices between the study groups (p<0.05). Discussion: We indicated that SII and and HALP scores may be cost-effective and easily accessible biomarkers in predicting asthma and both could be used as treatment response markers.