Selective NKCC1 Inhibitors for the Treatment of Neurodevelopmental and Neurological Disorders with Defective NKCC1/KCC2 expression-ratio

被引：1
|
作者：
Savardi, Annalisa [1 ]
Borgogno, Marco [1 ]
De Vivo, Marco [2 ]
Cancedda, Laura [2 ]
机构：
[1] Iama Therapeut, Genoa, Italy
[2] Ist Italiano Tecnol, Genoa, Italy
来源：
NEUROLOGY | 2023年 / 100卷 / 17期
关键词：
D O I：
10.1212/WNL.0000000000203467
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
P2-12.003
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function
    Liu, Ru
    Wang, Junling
    Liang, Shuli
    Zhang, Guojun
    Yang, Xiaofeng
    FRONTIERS IN NEUROLOGY, 2020, 10
  • [2] NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus
    Zhu, Lei
    Polley, Nathan
    Mathews, Gregory C.
    Delpire, Eric
    EPILEPSY RESEARCH, 2008, 79 (2-3) : 201 - 212
  • [3] NKCC1 and KCC2: Structural insights into phospho-regulation
    Hartmann, Anna-Maria
    Nothwang, Hans Gerd
    FRONTIERS IN MOLECULAR NEUROSCIENCE, 2022, 15
  • [4] Cation-Chloride Cotransporters KCC2 and NKCC1 as Therapeutic Targets in Neurological and Neuropsychiatric Disorders
    Lam, Patricia
    Newland, Julia
    Faull, Richard L. M.
    Kwakowsky, Andrea
    MOLECULES, 2023, 28 (03):
  • [5] Altered Expression of Regulators of the Cortical Chloride Transporters NKCC1 and KCC2 in Schizophrenia
    Arion, Dominique
    Lewis, David A.
    ARCHIVES OF GENERAL PSYCHIATRY, 2011, 68 (01) : 21 - 31
  • [6] The Cation Chloride Co-Transporters KCC2 and NKCC1 and Schizophrenia
    Hyde, Thomas M.
    BIOLOGICAL PSYCHIATRY, 2009, 65 (08) : 170S - 171S
  • [7] The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2
    Sensen Zhang
    Jun Zhou
    Yuebin Zhang
    Tianya Liu
    Perrine Friedel
    Wei Zhuo
    Suma Somasekharan
    Kasturi Roy
    Laixing Zhang
    Yang Liu
    Xianbin Meng
    Haiteng Deng
    Wenwen Zeng
    Guohui Li
    Biff Forbush
    Maojun Yang
    Communications Biology, 4
  • [8] Ketogenic diet does not change NKCC1 and KCC2 expression in rat hippocampus
    Gomez-Lira, Gisela
    Griselda Mendoza-Torreblanca, Julieta
    Granados-Rojas, Leticia
    EPILEPSY RESEARCH, 2011, 96 (1-2) : 166 - 171
  • [9] Developmental changes in KCC1, KCC2 and NKCC1 mRNAs in the rat cerebellum
    Mikawa, S
    Wang, C
    Shu, F
    Wang, T
    Fukuda, A
    Sato, K
    DEVELOPMENTAL BRAIN RESEARCH, 2002, 136 (02): : 93 - 100
  • [10] NKCC1 to KCC2 mRNA Ratio in Schizophrenia and Its Psychopathology: a Case–Control Study
    Hoorie Mohaghghegh
    Esmaeil Shahsavand Ananloo
    Mahmoudreza Hadjighasem
    Morteza Karimipour
    Shiva Hashemizadeh
    Seyyed Ali Ahmadi Abhari
    Journal of Molecular Neuroscience, 2022, 72 : 1670 - 1681
12345