In vitro cytotoxicity of Mn(i) and Ru(ii) carbonyls with a diphenyl pyridyl phosphine coligand towards leukaemia

被引：7

作者：

Mansour, Ahmed M. ^{[1
]}

Khaled, Rabaa M. ^{[1
]}

Radacki, Krzysztof ^{[2
]}

Younes, Zeina ^{[3
]}

Gamal, Mariam ^{[3
]}

Guirguis, Beatrice ^{[3
]}

Mostafa, Gamal A. E. ^{[4
]}

Ali, Essam A. ^{[4
]}

Shehab, Ola R. ^{[1
]}

机构：

[1] Cairo Univ, Fac Sci, Dept Chem, Gamma St, Cairo 12613, Giza, Egypt

[2] Julius Maximilians Univ Wurzburg, Inst Anorgan Chem, Am Hubland, D-97074 Wurzburg, Germany

[3] Cairo Univ, Fac Sci, Dept Biotechnol, Gamma St, Cairo 12613, Giza, Egypt

[4] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia

来源：

DALTON TRANSACTIONS | 2023年 / 52卷 / 30期

关键词：

EFFECTIVE CORE POTENTIALS; MOLECULAR CALCULATIONS; MONOXIDE RELEASE; VISIBLE-LIGHT; COMPLEXES; PHOTOCORMS;

D O I：

10.1039/d3dt01798b

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Human acute monocytic leukaemia cells were tested under both dark and light conditions for their susceptibility to Mn(i) and Ru(ii) carbonyl complexes with a diphenyl pyridyl phosphine coligand. The Ru(ii) complex (IC50 = 7.13 & PLUSMN; 0.8 & mu;M) displayed higher outstanding potency against leukaemia than the Mn(i) analogue (54.58 & PLUSMN; 4.1 & mu;M) in the dark and both complexes were completely harmless to healthy mouse bone marrow cells.

引用

页码：10286 / 10293

页数：8

共 3 条

[1] Light-activated cytotoxicity of dicarbonyl Ru(II) complexes with a benzimidazole coligand towards breast cancer
Ibrahim, Nourhan M.
Khaled, Rabaa M.
Ragheb, Mohamed A.
Radacki, Krzysztof
Farag, Ahmad M.
Mansour, Ahmed M.
DALTON TRANSACTIONS, 2021, 50 (42) : 15389 - 15399
[2] Rapid green and blue light-induced CO release from bromazepam Mn(I) and Ru(II) carbonyls: synthesis, density functional theory and biological activity evaluation
Mansour, Ahmed M.
APPLIED ORGANOMETALLIC CHEMISTRY, 2017, 31 (02)
[3] DNA-binding, topoisomerases I and II inhibition and in vitro cytotoxicity of ruthenium(II) polypyridyl complexes: [Ru(dppz)2L]2+ (L = dppz-11-CO2Me and dppz)
He, Xiaojun
Jin, Lianhe
Tan, Lifeng
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2015, 135 : 101 - 109

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