Amyloid-Inspired Engineered Multidomain Amphiphilic Injectable Peptide HydrogelAn Excellent Antibacterial, Angiogenic, and Biocompatible Wound Healing Material

Theingrained mechanical robustness of amyloids in associationwith their fine-tunable physicochemical properties results in therational design and synthesis of tailor-made biomaterials for specificapplications. However, the incredible antimicrobial efficacy of theseensembles has largely been overlooked. This research work providesan insight into the interplay between self-assembly and antimicrobialactivity of amyloid-derived peptide amphiphiles and thereby establishesa newfangled design principle toward the development of potent antimicrobialmaterials with superior wound healing efficacy. Apart from the relationshipwith many neurodegenerative diseases, amyloids are now consideredas an important cornerstone of our innate immune response againstpathogenic microbes. Impelled by this observation, a class of amphiphilicantimicrobial peptide-based biomaterial has been designed by takingA & beta;42 as a template. The designed AMP due to its amphipathicnature undergoes rapid self-assembly to form a biocompatible supramolecularhydrogel network having significant antibacterial as well as woundhealing effectivity on both Gram-negative P. aeruginosa and MRSA-infected diabetic wounds via reduced inflammatoryresponse and enhanced angiogenesis. Results suggest that disease-formingamyloids can be used as a blueprint for the fabrication of biomaterial-basedantimicrobial therapeutics by fine-tuning both the hydrophobicityof the & beta;-aggregation prone zone as well as membrane interactingcationic residues.