BRCA 1/2 mutations and risk of uterine cancer: a systematic review and meta-analysis

被引：0
|
作者：
Zakerinasab, Faezeh [1 ]
Behfar, Qumars [2 ,3 ]
Parsaee, Reza [4 ]
Zadeh, Reza Hossein [5 ]
Foroughi, Elaheh [6 ]
Amirbeik, Amirhesam [7 ]
Ahmadi, Ghazalehsadat [1 ]
机构：
[1] Mashhad Univ Med Sci, Mashhad, Iran
[2] Univ Cologne, Fac Med, Dept Neurol, Cologne, Germany
[3] Univ Cologne, Univ Hosp Cologne, Cologne, Germany
[4] Shiraz Univ Med Sci, Transplant Res Ctr, Shiraz, Iran
[5] Mashhad Univ Med Sci, Students Res Comm, Fac Med, Mashhad, Iran
[6] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran
[7] Mashhad Univ Med Sci, Student Res Comm, Sch Med, Mashhad, Iran
来源：
BMC GENOMIC DATA | 2024年 / 25卷 / 01期
关键词：
BRCA1; BRCA2; Mutation; Uterine cancer; Endometrial; ENDOMETRIAL CANCER; GERMLINE MUTATIONS; SEROUS CARCINOMA; JEWISH PATIENTS; WOMEN; PANELS;
D O I：
10.1186/s12863-024-01189-y
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Purpose In this study, we aim to investigate the association between BRCA1/2 mutation and uterine cancer incidence. Material and method We systematically searched three databases including PubMed, Scopus, and Google Scholar up to August 2023; and reviewed 23 cohorts and cross-sectional studies to explore the association between BRCA1/2 mutations and uterine cancer incidence. Results This systematic review comprised a total of 21 cohort studies and 2 cross-sectional studies after the screening process. According to meta-analysis the prevalence of the BRCA1/2 gene in patients with uterine cancer was 0.02 (95%CI = [0.01,0.03], P < 0.01, I-2 = 94.82%) Conclusions Our meta-analysis investigates a 2% prevalence of BRCA1/2 mutation in patients with uterine cancer. Patients with BRCA1/2 mutations might be more conscious of uterine malignancies.
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页数：11
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