Analysis of Predicted Amino Acid Sequences of Diatom Microtubule Center Components

被引:1
|
作者
Petrova, Darya P. [1 ]
Morozov, Alexey A. [1 ]
Potapova, Nadezhda A. [2 ]
Bedoshvili, Yekaterina D. [1 ]
机构
[1] Russian Acad Sci, Limnol Inst, Siberian Branch, Irkutsk 664033, Russia
[2] Russian Acad Sci, Inst Informat Transmiss Problems, Kharkevich Inst, Moscow 127051, Russia
基金
俄罗斯科学基金会;
关键词
diatoms; microtubule organizing center; gamma-complex protein; Aurora A; centrins; posttranslational modification; GAMMA-TUBULIN COMPLEXES; VALVE MORPHOGENESIS; CRYSTAL-STRUCTURE; CELL-DIVISION; SYNEDRA-ACUS; PROTEIN; AURORA; EVOLUTION; CENTRIN; NUCLEATION;
D O I
10.3390/ijms241612781
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Diatoms synthesize species-specific exoskeletons inside cells under the control of the cytoskeleton and microtubule center. Previous studies have been conducted with the visualization of the microtubule center; however, its composition has not been studied and reliably established. In the present study, several components of MTOC in diatoms, GCP (gamma complex proteins), Aurora A, and centrins have been identified. Analysis of the predicted amino acid sequences of these proteins revealed structural features typical for diatoms. We analyzed the conserved amino acids and the motives necessary for the functioning of proteins. Phylogenetic analysis of GCP showed that all major groups of diatoms are distributed over phylogenetic trees according to their systematic position. This work is a theoretical study; however, it allows drawing some conclusions about the functioning of the studied components and possible ways to regulate them.
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页数:14
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