The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders

被引：0

作者：

Borbye-Lorenzen, Nis ^{[1
]}

Zhu, Zhihong ^{[2
]}

Agerbo, Esben ^{[2
,3
,4
]}

Albinana, Clara ^{[2
,3
]}

Benros, Michael E. ^{[5
,6
]}

Bian, Beilei ^{[7
]}

Borglum, Anders D. ^{[3
,8
,9
,10
]}

Bulik, Cynthia M. ^{[11
,12
,13
]}

Debost, Jean-Christophe Philippe Goldtsche ^{[2
,14
]}

Grove, Jakob ^{[3
,10
,15
,16
]}

Hougaard, David M. ^{[3
,17
]}

McRae, Allan F. ^{[7
]}

Mors, Ole ^{[3
,18
]}

Mortensen, Preben Bo ^{[3
,4
]}

Musliner, Katherine L. ^{[19
,20
]}

Nordentoft, Merete ^{[3
,21
]}

Petersen, Liselotte V. ^{[2
]}

Prive, Florian ^{[2
]}

Sidorenko, Julia ^{[7
]}

Skogstrand, Kristin ^{[1
]}

Werge, Thomas ^{[3
,22
,23
,24
]}

Wray, Naomi R. ^{[7
,25
,26
,27
]}

Vilhjalmsson, Bjarni J. ^{[2
,3
,16
]}

McGrath, John J. ^{[2
,25
,28
]}

机构：

[1] Statens Serum Inst, Ctr Neonatal Screening, Dept Congenital Disorders, Copenhagen, Denmark

[2] Aarhus Univ, Natl Ctr Register Based Res, DK-8210 Aarhus V, Denmark

[3] Lundbeck Fdn Initiat Integrat Psychiat Res, iPSYCH, DK-8210 Aarhus V, Denmark

[4] Aarhus Univ, Ctr Integrated Register Based Res, CIRRAU, DK-8210 Aarhus V, Denmark

[5] Copenhagen Univ Hosp, Copenhagen Res Ctr Mental Hlth, Mental Hlth Ctr Copenhagen, CORE, Hellerup, Denmark

[6] Univ Copenhagen, Fac Hlth & Med Sci, Dept Immunol & Microbiol, Copenhagen, Denmark

[7] Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia

[8] Aarhus Univ, Dept Biomed, Aarhus, Denmark

[9] Aarhus Univ, iSEQ Ctr, Aarhus, Denmark

[10] Ctr Genom & Personalized Med, Aarhus, Denmark

[11] Univ North Carolina Chapel Hill, Dept Psychiat, Chapel Hill, NC USA

[12] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[13] Univ North Carolina Chapel Hill, Dept Pediat, Chapel Hill, NC USA

[14] Aarhus Univ Hosp Skejby, Dept Psychosis, Aarhus Nord, Denmark

[15] Aarhus Univ, Dept Biomed Human Genet, Aarhus, Denmark

[16] Aarhus Univ, Bioinformat Res Ctr, DK-8000 Aarhus C, Denmark

[17] Statens Serum Inst, Dept Congenital Disorders, DK-2300 Copenhagen S, Denmark

[18] Aarhus Univ Hosp Psychiat, Psychosis Res Unit, Aarhus, Denmark

[19] Aarhus Univ, Dept Affect Disorders, Aarhus, Denmark

[20] Aarhus Univ Hosp, Psychiat, Aarhus, Denmark

[21] Univ Copenhagen, Mental Hlth Ctr Copenhagen, Mental Hlth Serv Capital Reg Denmark, DK-2100 Copenhagen, Denmark

[22] Univ Copenhagen, Dept Clin Med, DK-2200 Copenhagen N, Denmark

[23] Copenhagen Univ Hosp, Univ Copenhagen, Inst Biol Psychiat, Dept Clin Med,Mental Health Serv, DK-2200 Copenhagen N, Denmark

[24] Univ Copenhagen, GLOBE Inst, Lundbeck Ctr Geogenet, Copenhagen, Denmark

[25] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia

[26] Univ Oxford, Dept Psychiat, Oxford OX3 7JX, England

[27] Univ Oxford, Big Data Inst, Oxford OX3 7LF, England

[28] Pk Ctr Mental Hlth, Queensland Ctr Mental Hlth Res, Brisbane, Qld 4076, Australia

来源：

CELL GENOMICS | 2023年 / 3卷 / 12期

基金：

澳大利亚国家健康与医学研究理事会; 澳大利亚研究理事会; 瑞典研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; GENETIC ARCHITECTURES; SCHIZOPHRENIA-RISK; SYSTEM; COMMON; LOCI; GWAS; C4; VALIDITY; DISEASES;

D O I：

10.1016/j.xgen.2023.100457

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Complement components have been linked to schizophrenia and autoimmune disorders. We examined the association between neonatal circulating C3 and C4 protein concentrations in 68,768 neonates and the risk of six mental disorders. We completed genome-wide association studies (GWASs) for C3 and C4 and applied the summary statistics in Mendelian randomization and phenome-wide association studies related to mental and autoimmune disorders. The GWASs for C3 and C4 protein concentrations identified 15 and 36 independent loci, respectively. We found no associations between neonatal C3 and C4 concentrations and mental disorders in the total sample (both sexes combined); however, post-hoc analyses found that a higher C3 concentration was associated with a reduced risk of schizophrenia in females. Mendelian randomization based on C4 summary statistics found an altered risk of five types of autoimmune disorders. Our study adds to our understanding of the associations between C3 and C4 concentrations and subsequent mental and autoimmune disorders.

引用

页数：24

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