Pneumothorax, pneumomediastinum, and subcutaneous emphysema in hospitalized COVID-19 patients: incidence, clinical characteristics, and outcomes

被引:0
|
作者
Baptista, Aleksandra Murawska [1 ]
De Frias, Jorge Sinclair [2 ]
Singh, Trisha [2 ]
Vasudhar, Ananya [2 ]
Guzzino, Jacob [1 ]
Khalili, Waheed [1 ]
Tekin, Aysun [3 ]
Bansal, Vikas [3 ]
Kashyap, Rahul [3 ]
Joyce, William J. [1 ]
Lewis, Patricia A. [1 ]
Sanghavi, Devang [2 ]
Gavrancic, Tatjana [1 ]
Franco, Pablo Moreno [2 ]
机构
[1] Mayo Clin, Dept Hosp Internal Med, 4500 San Pablo Rd S, Jacksonville, FL 32224 USA
[2] Mayo Clin, Dept Crit Care Med, Jacksonville, FL 32224 USA
[3] Mayo Clin, Dept Anesthesiol & Crit Care Med, Rochester, MN USA
关键词
Pneumothorax; pneumomediastinum; subcutaneous emphysema; COVID-19; SARS-CoV-2; CORONAVIRUS DISEASE 2019; RESPIRATORY ILLNESS UNIVERSAL; VIRAL-INFECTION;
D O I
10.1080/17476348.2023.2254689
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
BackgroundLimited data is available on the incidence and outcomes of pneumothorax (PTX), pneumomediastinum (PNM), and subcutaneous emphysema (SCE) in COVID-19 patients. This study aimed to investigate the characteristics of these complications in hospitalized COVID-19 patients.Research design and methodsA retrospective study was conducted, involving adult COVID-19 patients admitted to Mayo Clinic Florida from 03/2020-06/2022. Patients were divided into two groups based on the presence or absence of PTX/PNM/SCEResults1926 hospitalized patients with COVID-19 were included, of which 518 were admitted to the ICU. The incidence of PTX/PNM/SCE was 6.3%. Patients with these complications were more likely to be male, Asian, and unvaccinated. Conversely, they were less likely to have chronic obstructive pulmonary disease. Patients who developed PTX/PNM/SCE after 72 hours of admission were more likely to receive high-dose corticosteroids and for an extended duration. The affected group had an adjusted odds ratio for in-hospital mortality of 13.32 (95%CI, 8.19-21.59) and ICU admission of 9.14 (95%CI, 5.3-12.78) compared to the unaffected group.ConclusionAlthough the occurrence of PTX/PNM/SCE in hospitalized COVID-19 patients was rare, it was associated with worse outcomes. Corticosteroids may contribute to the pathogenesis of these complications; however, further studies are needed to investigate this relationship in more detail.
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页码:727 / 733
页数:7
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