Three-Component 1,4-Addition through Ugi-Type Reaction, an Oxidative Dearomatization Strategy

被引：0
|
作者：
Chen, Zhihao [1 ,2 ]
Liu, Yuqing [1 ]
Gao, Xing [2 ]
Sun, Yuanyuan [2 ]
Lei, Lingyu [2 ]
Zhao, Xia [1 ]
Lu, Kui [2 ]
机构：
[1] Tianjin Normal Univ, Coll Chem, Tianjin Key Lab Struct & Performance Funct Mol, Tianjin 300387, Peoples R China
[2] Tianjin Univ Sci & Technol, Coll Biotechnol, China Int Sci & Technol Cooperat Base Food Nutr Sa, Tianjin 300457, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 13卷 / 01期
基金：
中国国家自然科学基金;
关键词：
1,4-addition; Diversity-oriented synthesis; Multicomponent reactions; Oxidative dearomatization; Ugi reaction; MULTICOMPONENT REACTIONS; INTERRUPTED UGI; DOMINO REACTION; CONSTRUCTION; ISOCYANIDE; ACCESS; SMILES; 2-ALKYNYLANILINES; CYCLOADDITION; ISONITRILE;
D O I：
10.1002/ajoc.202300502
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A three-component 1,4-addition variant of the Ugi reaction involving carboxylic acids, isocyanides, and cyclic alpha,beta-unsaturated imines is presented in this study. The cyclic alpha,beta-unsaturated imines were conveniently prepared through the oxidative dearomatization of N-substituted anilines. The reaction proceeded successfully to produce a sole diastereomer, and the relative configuration was determined through 2D NMR and X-ray diffraction analysis.
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页数：5
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