Interleukin-13 inhibition by tralokinumab reduces inducible T-cell costimulator-positive innate lymphoid cells in skin lesions of atopic dermatitis

被引：0

作者：

Kogame, Toshiaki ^{[1
]}

Yonekura, Satoru ^{[1
]}

Lovato, Paola ^{[2
]}

Hirata, Masahiro ^{[3
]}

Takimoto-ito, Riko ^{[1
]}

Takegami, Tomoya ^{[1
]}

Komatsu-Fujii, Takayoshi ^{[1
]}

Kambe, Naotomo ^{[1
]}

Nomura, Takashi ^{[1
]}

Ropke, Mads A. ^{[2
]}

Kabashima, Kenji ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Dermatol, Kyoto, Japan

[2] LEO Pharm A S, Ballerup, Denmark

[3] Kyoto Univ Hosp, Dept Diagnost Pathol, Kyoto, Japan

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2023年 / 188卷 / 01期

关键词：

D O I：

10.1093/bjd/ljac008

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Despite the low frequency of skin ILCs and the limited number of samples analyzed in this study, our data indicate that ICOS+ ILCs express IL-13Ra1 and that the density of ICOS+ ILCs decreased four weeks after initiation of treatment with tralokinumab.

引用

页码：146 / 148

页数：3

共 4 条

[1] Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator-inducible T-cell costimulator ligand interaction
Rigas, Diamanda
Lewis, Gavin
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Wang, Bowen
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Sankaranarayanan, Ishwarya
Galle-Treger, Lauriane
Maazi, Hadi
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Sharpe, Arlene H.
Soroosh, Pejman
Akbari, Omid
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 139 (05) : 1468 - +
[2] T helper 22 cells from Han Chinese patients with atopic dermatitis exhibit high expression of inducible T-cell costimulator
Jiao, Q.
Qian, Q.
Liu, C.
Luo, Y.
Fang, F.
Wang, M.
Ji, J.
Qian, H.
Zhang, X.
Maurer, M.
BRITISH JOURNAL OF DERMATOLOGY, 2020, 182 (03) : 648 - 657
[3] Interleukin-13 and interferon-gamma producing skin resident CD8+ T cells:: a vicious circle of barrier disruption of the skin in atopic dermatitis
Hijnen, D. I.
Bruijnzeel-Koomen, C. A.
Haeck, I. M.
Knol, E. F.
de Bruin-Weller, M. S.
Kupper, T. S.
Clark, R. A.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2008, 128 : S14 - S14
[4] Calcitonin gene-related peptide modulates interleukin-13 in circulating cutaneous lymphocyte-associated antigen-positive T cells in patients with atopic dermatitis
Antunez, C.
Torres, M. J.
Lopez, S.
Rodriguez-Pena, R.
Blanca, M.
Mayorga, C.
Santamaria-Babi, L. F.
BRITISH JOURNAL OF DERMATOLOGY, 2009, 161 (03) : 547 - 553

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