In vitro anti-tumoral and immunomodulatory effects of acidic polysaccharides isolated from the fungus Gloeosoma mirabile

被引：0

作者：

Torres, Solange ^{[1
]}

Figueroa, Fabian ^{[1
]}

Arrojo, Virginia Casas ^{[2
]}

Riquelme, Cristian ^{[3
,4
]}

Astuya, Allisson ^{[5
]}

Abdala-Diaz, Roberto T. ^{[2
]}

Becerra, Jose ^{[1
,6
]}

Rajchenberg, Mario ^{[7
]}

Pildain, Maria Belen ^{[7
]}

Baltazar, Juliano Marcon ^{[8
]}

Cabrera-Pardo, Jaime R. ^{[9
]}

Perez, Claudia ^{[1
,6
]}

机构：

[1] Univ Concepcion, Fac Ciencias Nat & Oceanograf, Dept Bot, Concepcion, Chile

[2] Univ Malaga, Fac Sci, Dept Ecol, Malaga, Spain

[3] Univ Austral Chile, Escuela Grad, Fac Ciencias, Programa Doctorado Ciencias Menc Ecol & Evoluc, Valdivia, Chile

[4] Univ Austral Chile, Lab Micol, Inst Bioquim & Microbiol, Valdivia, Chile

[5] Univ Concepcion, Fac Ciencias Nat & Ciencias Oceanograf, Dept Oceanog, Concepcion, Chile

[6] Univ Concepcion, Unidad Desarrollo Tecnol, UDT, Concepc, Chile

[7] CIEFAP Ctr Invest & Extens Forestal Andino Patagon, Esquel, Chubut, Argentina

[8] Univ Fed Sao Carlos, Ctr Ciencias Nat, Buri, Brazil

[9] Univ Bio Bio, Dept Quim, Lab Quim Aplicada & Sustentable LabQAS, Concepcion, Chile

来源：

NATURAL PRODUCT RESEARCH | 2024年

关键词：

Gloeosoma mirabile; polysaccharides; antitumoral; immunomodulatory;

D O I：

10.1080/14786419.2024.2335351

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Polysaccharides from wood-rooting fungi have attracted attention due to their broad pharmacological properties. Herein, we report the antitumor and immunomodulatory activities of acid polysaccharides isolated from fungi Gloeosoma mirabile. The polysaccharide extracts displayed significant antiproliferative activity against cancer cell lines (MCF-7, HCT-116, U-937) in a dose-dependent manner and induction of IL-6 in macrophage RAW 264.7. Furthermore, flow cytometry analysis showed that high polysaccharide concentrations induced apoptosis by 83% in HL-60 cells. Based on gas chromatography-mass spectrometry (GC-MS) and Fourier transform infra-red (FT-IR) spectroscopy studies, acidic polysaccharides from G. mirabile were mainly composed of arabinose, alpha-D-galactopyranose and methyl beta-D-galactopyranoside.

引用

页数：6

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