Syphilis is caused by Treponema pallidum and is recognized by the variety of its clinical manifestations; it involves the nervous, integumentary and cardiovascular systems. Cardiovascularalterations occur in 70% of cases with untreated syphilis, 71% of syphilitic aortitis develop aorticaneurysms and the most frequent complication is aortic insufficiency. Treatment is directed at the underlying disease, with antibiotic treatment for tertiary syphilis and thromboemboliccomplications and if necessary surgical repair. We present a rare case of a patient diagnosed withhuman immunodeficiency virus infection and cardiovascular complications typical of tertiarysyphilis, who required medical and surgical treatment, which was successful. We highlight theclinical experience of our institution ' s professionals in the diagnosis and identification ofcardiovascular complications of tertiary syphilis.