Purpose: To analyze the poten-al associa-on between the occlusion features and the incidence of temporomandibular joint (TMJ) arthralgia in pa-ents with par-al dentures. Materials and Methods: A total of 101 par-al denture wearers were collected, 45 with unilateral TMJ arthralgia diagnosed according to the Diagnos-c Criteria for Temporomandibular Disorders (DC/TMD). Binary logis-c regression analysis was adopted. The TMJ asymptoma-c group (n = 45) was quan-fied as 0, while the TMJ arthralgia group (n = 56) was quan-fied as 1. In total, 13 occlusion variables were analyzed: gender, age, number of prosthe-c teeth, number of den--on quadrants with a prosthe-c tooth, anterior or posterior prosthesis loca-on in maxillary or mandibular den--on, occluded prosthesis pair, anterior overjet, and overbite rela-on. Simple and mul-ple binary logis-c models were adopted, accordingly, for the risk impact of them on TMJ arthralgia. Results: Overbite (OR = 2.238) and maxillary anterior prosthesis (OR = 0.305) were entered into the simple binary logis-c model; while overbite (OR = 2.774) plus maxillary anterior prosthesis (OR = 0.347), overbite (OR = 3.425) plus unilateral maxillary posterior prosthesis (OR = 4.672), and overbite (OR = 3.476) plus overjet (OR = 0.436) and mandibular anterior prosthesis (OR = 0.177) were entered into the mul-variate logis-c regression model (all, P <.05). Conclusions: Par-al denture wearers with a deep overbite, especially those with a unilateral maxill ary posterior prosthesis, had a higher prevalence of unilateral TMJ arthralgia.