Investigating the properties and biological activity of a new Cu(II) complex with a 2-Dimethyaminopyridinium cation (C7H12N2)2[CuCl4]

A new single crystal of (C7H12N2)2[CuCl4] was developed at room temperature using the gradual evapo-ration technique, resulting in an interesting structural arrangement. The crystal is composed of alternat-ing organic and inorganic layers that are held together by the cohesive force of H-bonds formed between the organic and inorganic groups, as well as interactions controlled by Van der Waals forces. The distri-bution of intermolecular interactions was explored using Hirshfeld surface analysis, revealing that H. ..H contacts make up a substantial portion of the Hirshfeld surface. To uncover the vibrational features of this structure, infrared spectroscopy was employed, and the vibrational bands were assigned by comparing the frequencies to those of similar compounds. With the increasing issue of multi-drug-resistant bacteria, the potential for a synergistic effect between antibiotics and metal ion complexes is becoming more crit-ical. This was tested by combining antibiotics with (C7H12N2)2[CuCl4] and investigating their antibacterial activity using disk diffusion techniques, which showed a synergistic increase in activity against oppor-tunistic nosocomial pathogen bacterial strains. & COPY; 2023 The Author. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).