Structural characterization of water-soluble polysaccharides from Sophora flavescens Ait. and their anti-inflammatory activities based on NO release

被引：1

作者：

Li, Yi-Xuan ^{[1
,2
]}

Lu, Bo-Wen ^{[1
,2
]}

Jiang, Si-Liang ^{[1
,2
]}

Dong, Cai-Xia ^{[2
]}

Du, Juan ^{[1
]}

机构：

[1] Jiamusi Univ, Coll Pharm, Dept Pharmacognosy, Jiamusi 154007, Peoples R China

[2] Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 2023年 / 41卷 / 7-9期

基金：

中国国家自然科学基金;

关键词：

Anti-inflammatory effect; polysaccharide; Sophora flavescens Ait; structural characterization; ESTERIFICATION; ANTIOXIDANT;

D O I：

10.1080/07328303.2023.2174551

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sophora flavescens Ait. is a medicinal herb traditionally used to treat inflammatory diseases. In this study, four polysaccharides, SFNP-1, SFNP-2, SFAP-1, and SFAP-2, were isolated from S. flavescens. Both SFNP-1 and SFNP-2 were (1 -> 4)-linked glucans. SFAP-1 and SFAP-2 were identified as pectin-type polysaccharides containing mainly a homo-galacturanan backbone (as shown). NO release inhibition test revealed that the major polysaccharides, SFAP-1 and SFAP-2, did not have a significant anti-inflammatory effect. This result suggests that the anti-inflammatory effect of S. flavescens may not depend on its polysaccharides.

引用

页码：405 / 423

页数：19

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