Whole Genome and Transcriptomic Profiling of Pancreatic Acinar Cell Carcinoma Elucidates Signatures of Homologous Recombination Deficiency and Unravels Novel Fusion Events

被引:0
|
作者
Karaaslan, Selda [1 ]
Al Assaad, Majd [1 ]
Hadi, Kevin
Deshpande, Aditya
Manohar, Jyothi [2 ]
Sigouros, Michael [2 ]
Elsaeed, Ahmed [2 ]
Sboner, Andrea [2 ]
Medina-Martinez, Juan [2 ]
Jessurun, Jose [1 ]
Elemento, Olivier [2 ]
Mosquera, Juan Miguel [2 ]
机构
[1] New York Presbyterian Weill Cornell Med, New York, NY USA
[2] Weill Cornell Med, New York, NY USA
关键词
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
1477
引用
收藏
页码:S1510 / S1511
页数:2
相关论文
共 19 条
  • [1] Whole genome and transcriptome analysis of pancreatic acinar cell carcinoma elucidates mechanisms of homologous recombination deficiency and unravels novel relevant fusion events
    Delgado-de la Mora, Jesus
    Al Assaad, Majd
    Karaaslan, Selda
    Hadi, Kevin
    Halima, Ahmed
    Deshpande, Aditya
    Manohar, Jyothi
    Sigouros, Michael
    Medina-Martinez, Juan S.
    Lieberman, Michael D.
    Sboner, Andrea
    Popa, Elizabeta C.
    Elemento, Olivier
    Jessurun, Jose
    Ocean, Allyson J.
    Hissong, Erika
    Mosquera, Juan Miguel
    PATHOLOGY RESEARCH AND PRACTICE, 2025, 266
  • [2] Whole genome and transcriptome analysis of pancreatic acinar cell carcinoma elucidates mechanisms of homologous recombination deficiency and unravels novel relevant fusion events (vol 266, 155798, 2025)
    Delgado-de la Mora, Jesus
    Al Assaad, Majd
    Karaaslan, Selda
    Hadi, Kevin
    Halima, Ahmed
    Deshpande, Aditya
    Manohar, Jyothi
    Sigouros, Michael
    Medina-Martinez, Juan S.
    Lieberman, Michael D.
    Sboner, Andrea
    Popa, Elizabeta C.
    Jessurun, Jose
    Elemento, Olivier
    Ocean, Allyson J.
    Hissong, Erika
    Mosquera, Juan Miguel
    PATHOLOGY RESEARCH AND PRACTICE, 2025, 266
  • [3] Genomic Profiling Reveals Germline Predisposition and Homologous Recombination Deficiency in Pancreatic Acinar Cell Carcinoma
    Mandelker, Diana
    Marra, Antonio
    Zheng-Lin, Binbin
    Selenica, Pier
    Blanco-Heredia, Juan
    Zhu, Yingjie
    Gazzo, Andrea
    Wong, Donna
    Yelskaya, Zarina
    Rai, Vikas
    Somar, Joshua
    Ostafi, Silvana
    Mehta, Nikita
    Yang, Ciyu
    Li, Yirong
    Brown, David N.
    da Silva, Edaise M.
    Pei, Xin
    Linkov, Irina
    Terraf, Panieh
    Misyura, Maksym
    Ceyhan-Birsoy, Ozge
    Ladanyi, Marc
    Berger, Michael
    Pareja, Fresia
    Stadler, Zsofia
    Offit, Kenneth
    Riaz, Nadeem
    Park, Wungki
    Chou, Joanne
    Capanu, Marinela
    Koehler, Maria
    Rosen, Ezra
    O'Reilly, Eileen M.
    Reis-Filho, Jorge S.
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (33) : 5151 - +
  • [4] AcornHRD: A novel tool to identify homologous recombination deficiency events in whole genome sequencing data.
    Liu, Kai
    Hao, Xueyu
    Zhang, Mengmeng
    Li, Mingwei
    Wang, Wang
    Zhang, Xinhao
    Guo, Jing
    Wang, Huina
    Lou, Feng
    Cao, Shanbo
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [5] Whole Genome Profiling of Primary and Metastatic Adrenocortical Carcinoma Unravels Significant Molecular Events
    Kalomeris, Taylor
    Al Assaad, Majd
    Gundem, Gunes
    Levine, Max
    Elsaeed, Ahmed
    Manohar, Jyothi
    Sigouros, Michael
    Medina-Martinez, Juan
    Sboner, Andrea
    Elemento, Olivier
    Mosquera, Juan Miguel
    LABORATORY INVESTIGATION, 2023, 103 (03) : S492 - S494
  • [6] Whole genome profiling of primary and metastatic adrenocortical carcinoma unravels significant molecular events
    Kalomeris, Taylor
    Al Assaad, Majd
    Mora, Jesus Delgado-de la
    Gundem, Gunes
    Levine, Max F.
    Boyraz, Baris
    Manohar, Jyothi
    Sigouros, Michael
    Medina-Martinez, Juan S.
    Sboner, Andrea
    Elemento, Olivier
    Scognamiglio, Theresa
    Mosquera, Juan Miguel
    PATHOLOGY RESEARCH AND PRACTICE, 2025, 266
  • [7] Whole Genome Sequencing (WGS) of Locally Advanced and Metastatic Breast Carcinoma Unravels Relevant Molecular Signatures and Novel Events
    Phan, Andy
    Al Assaad, Majd
    Gundem, Gunes
    Levine, Max
    Manohar, Jyothi
    Sigouros, Michael
    Elsaeed, Ahmed
    Sboner, Andrea
    Hoda, Syed
    Medina-Martinez, Juan
    Elemento, Olivier
    Mosquera, Juan Miguel
    LABORATORY INVESTIGATION, 2023, 103 (03) : S196 - S197
  • [8] Paediatric pancreatic acinar cell carcinoma with a novel SEC31A-BRAF fusion gene
    Li, Tingting
    Cheng, Yin
    Han, Yixuan
    Yang, Li
    Wei, Qiang
    Yan, Xiaosong
    Shi, Yue
    Zhang, Xin
    Yang, Meng
    Liu, Yanfei
    VIRCHOWS ARCHIV, 2024, 485 (04) : 743 - 747
  • [9] Diagnosing primary pancreatic acinar cell carcinoma-Clinical correlation of radiological/molecular imaging, histopathologic features and whole genome/transcriptome profiling, and review of the literature
    Tran, Kevin
    Prall, Owen W. J.
    Mitchell, Catherine
    Chou, Angela
    Gill, Anthony J.
    Grimmond, Sean M.
    Kong, Grace
    Kiernan, Gareth
    Torche, Cristina
    Lipton, Lara
    Thomson, Benjamin
    Ko, H. S.
    CURRENT PROBLEMS IN CANCER: CASE REPORTS, 2023, 9
  • [10] Genomic scar signatures associated with homologous recombination deficiency predict adverse clinical outcomes in patients with ovarian clear cell carcinoma
    Angel Chao
    Chyong-Huey Lai
    Tzu-Hao Wang
    Shih-Ming Jung
    Yun-Shien Lee
    Wei-Yang Chang
    Lan-Yang Yang
    Fei-Chun Ku
    Huei-Jean Huang
    An-Shine Chao
    Chin-Jung Wang
    Ting-Chang Chang
    Ren-Chin Wu
    Journal of Molecular Medicine, 2018, 96 : 527 - 536