Tirucallane-type triterpenoid from the stem bark of Chisocheton lasiocarpus and its cytotoxic activity against MCF-7 breast cancer cells

被引：0

作者：

Parulian, Samuel San ^{[1
]}

Naini, Al Arofatus ^{[1
]}

Hilmayanti, Erina ^{[1
,2
]}

Farabi, Kindi ^{[1
]}

Harneti, Desi ^{[1
]}

Mayanti, Tri ^{[1
]}

Maharani, Rani ^{[1
,3
]}

Herlina, Tati ^{[1
]}

Supratman, Unang ^{[1
,3
]}

Anwar, Risyandi ^{[4
]}

Fajriah, Sofa ^{[5
]}

Azmi, Mohamad Nurul ^{[6
]}

Prescott, Thomas ^{[7
]}

Shiono, Yoshihito ^{[8
]}

机构：

[1] Univ Padjadjaran, Fac Math & Nat Sci, Dept Chem, Jatinangor 45363, Indonesia

[2] Osaka Univ, Grad Sch Sci, Dept Chem, Toyonaka 5600043, Japan

[3] Univ Padjadjaran, Cent Lab, Jatinangor 45363, Indonesia

[4] Univ Muhammadiyah Semarang, Fac Dent Med, Dept Pediat Dent, Herbal Med Res, Semarang 50272, Indonesia

[5] Natl Res & Innovat Agcy BRIN Kawasan PUSPIPTEK Se, Res Ctr Chem, Banten 15314, Indonesia

[6] Univ Sains Malaysia, Sch Chem Sci, Minden 11800, Malaysia

[7] Royal Bot Gardens, Richmond TW9 3AB, England

[8] Yamagata Univ, Fac Agr, Dept Food Life & Environm Sci, Tsuruoka 9978555, Japan

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2023年 / 25卷 / 08期

关键词：

Chisocheton lasiocarpus; Meliaceae; triterpenoid; cytotoxic activity; MCF-7; LIMONOIDS;

D O I：

10.1080/10286020.2022.2143353

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chisocarpene A (1) is a new tirucallane-type triterpenoid together with odoratone (2) and 24-methylenecycloartanol (3), isolated from the stem bark of Chisocheton lasiocarpus. The chemical structures of compounds 1-3 were elucidated through a detailed analysis of their spectroscopic data (IR, MS, 1 D, and 2 D NMR). The isolated compounds were evaluated for cytotoxic activity against the MCF-7 breast cancer cell line using a resazurin-based assay. Compound 1 showed the most potent activity (IC50 26.56 +/- 1.01 mu M) and was two-fold more active than the positive control.

引用

页码：803 / 809

页数：7

共 50 条

[1] Triterpenoids from Stem Bark of Dysoxylum excelsum and Their Cytotoxic Activity against MCF-7 Breast Cancer Cells
Meilanie, Sylvia Rachmawati
Mayanti, Tri
Nurlelasari, Nurlelasari
Putri, Desi Harneti
Maharani, Rani
Zainuddin, Achmad
Darwati, Darwati
Julaeha, Euis
Supratman, Unang
Anshori, Jamaludin Al
INDONESIAN JOURNAL OF CHEMISTRY, 2022, 22 (04) : 1107 - 1115
[2] Cytotoxic Constituents from the Bark of Erythrina poeppigiana Against the MCF-7 Breast Cancer Cell Lines
Herlina, Tati
Merlin
Azlan, Mohd.
Supratman, Unanatr
NATURAL PRODUCTS JOURNAL, 2020, 10 (03): : 257 - 261
[3] Cytotoxic activity of nemorosone in human MCF-7 breast cancer cells
Popolo, Ada
Piccinelli, Anna Lisa
Morello, Silvana
Sorrentino, Rosalinda
Rubio Osmany, Cuesta
Rastrelli, Luca
Aldo, Pinto
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2011, 89 (01) : 50 - 57
[4] Antitumor activity of the Ailanthus altissima bark phytochemical ailanthone against breast cancer MCF-7 cells
Wang, Ruxing
Lu, Yanjie
Li, Hong
Sun, Lixin
Yang, Ning
Zhao, Mingzhen
Zilang, Manli
Shi, Qingwen
ONCOLOGY LETTERS, 2018, 15 (04) : 6022 - 6028
[5] Sesquiterpenoids from the Stem Bark of Lansium domesticum Corr. Cv. Kokossan and Their Cytotoxic Activity against MCF-7 Breast Cancer Cell Lines
Sinaga, Siska Elisahbet
Mayanti, Tri
Naini, Al Arofatus
Harneti, Desi
Nurlelasari, Nurlelasari
Maharani, Rani
Farabi, Kindi
Supratman, Unang
Fajriah, Sofa
Azmi, Mohamad Nurul
INDONESIAN JOURNAL OF CHEMISTRY, 2022, 22 (04) : 1035 - 1042
[6] Antioxidant and cytotoxic activity of isoindole compounds in breast cancer cells (MCF-7)
Mesci, Seda
Gul, Melek
Eryilmaz, Serpil
Lis, Tadeusz
Szafert, Slawomir
Yildirim, Tuba
JOURNAL OF MOLECULAR STRUCTURE, 2020, 1217
[7] Triterpenoid of avocado (Persea americana) seed and its cytotoxic activity toward breast MCF-7 and liver HepG2 cancer cells
Abubakar, Andi Nur Fitriani
Achmadi, Suminar Setiati
Suparto, Irma Herawati
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE, 2017, 7 (05) : 397 - 400
[8] CYTOTOXIC COMPOUNDS AGAINST BREAST ADENOCARCINOMA CELLS (MCF-7) FROM PIKUTBENJAKUL
Sakpakdeejaroen, Intouch
Itharat, Arunporn
JOURNAL OF HEALTH RESEARCH, 2009, 23 (02) : 71 - 76
[9] Triterpenoid of avocado (Persea americana) seed and its cytotoxic activity toward breast MCF-7 and liver HepG2 cancer cells
Andi Nur Fitriani Abubakar
Suminar Setiati Achmadi
Irma Herawati Suparto
Asian Pacific Journal of Tropical Biomedicine, 2017, (05) : 397 - 400
[10] Sesquiterpenoids from Dysoxylum amooroides Stem Bark: Isolation, Structure Determination, and Cytotoxicity Against MCF-7 Breast Cancer Cells
Gunawan, Latifah
Mustofa, Hidayat Nurul
Naini, Al Arofatus
Harneti, Desi
Hidayat, Ace Tatang
Nurlelasari, Nurlelasari
Maharani, Rani
Mayanti, Tri
Fajriah, Sofa
Awang, Khalijah
Azmi, Mohamad Nurul
Supratman, Unang
INDONESIAN JOURNAL OF CHEMISTRY, 2025, 25 (01) : 157 - 168

← 1 2 3 4 5 →