Stereolithography of ceramic scaffolds for bone tissue regeneration: Influence of hydroxyapatite/silica ratio on mechanical properties

被引：1
|
作者：
Rstakyan, Viktorya [1 ]
Mkhitaryan, Liana [1 ]
Baghdasaryan, Lilit [1 ]
Ghaltaghchyan, Tsovinar [1 ]
Karabekian, Zaruhi [2 ]
Sevoyan, Gohar [2 ]
Aghayan, Marina [1 ,3 ]
Rodriguez, Miguel A. [4 ]
机构：
[1] Natl Acad Sci Republ Armenia, AB Nalbandyan Inst Chem Phys, P Sevak 5-2, Yerevan 0014, Armenia
[2] Natl Acad Sci Armenia, Orbeli Inst Physiol, Orbeli Bros 22, Yerevan 0028, Armenia
[3] FACT Ind, Oismae Tee 124, EE-13513 Tallinn, Estonia
[4] Inst Ceram & Vidrio CSIC, C Kelsen 5, Madrid 28049, Spain
来源：
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS | 2024年 / 152卷
关键词：
Sintering; Biomaterials; Stereolithography; Hydroxyapatite; Scaffolds; TRICALCIUM PHOSPHATE; SIO2; SRO; ZNO; MGO;
D O I：
10.1016/j.jmbbm.2024.106421
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this paper, the results obtained in the development of ceramic resin feedstock for stereolithography are shown. Hydroxyapatite and silica are used as source of ceramic. Hydroxyapatite is extracted from bovine bone, which enhances bioactivity of ceramic scaffold. The influence of hydroxyapatite amount in polymer-based slurry on the viscosity and printability of feedstock is explored. Hydroxyapatite and silica containing scaffolds are successfully obtained by stereolithography. Influence of hydroxyapatite/silica ratio on the bioactivity, biodegradability and mechanical properties of the scaffolds is also studied. It was observed that higher concentrations of hydroxyapatite led to improved mechanical strength of the scuffolds but increased viscosity of the slurry, affecting printability. Cell viability assays and cell visualization experiments indicated that the scaffolds not cause significant cell toxicity.
引用
收藏
页数：7
相关论文
共 50 条
  • [1] Production of ceramic alumina scaffolds via ceramic stereolithography with potential application in bone tissue regeneration
    Duque-Uribe, Carolina
    López-Vargas, Valentina
    Moreno-Florez, Ana Isabel
    Pelaez-Vargas, Alejandro
    Ossa, Alex
    Cárdenas-Ramírez, Carolina
    Restrepo-Vélez, Sebastián
    Vásquez, Andrés Felipe
    Garcia, Claudia
    [J]. Materials Today Communications, 2024, 40
  • [2] Porous ceramic bone scaffolds for vascularized bone tissue regeneration
    Julia Will
    Reinhold Melcher
    Cornelia Treul
    Nahum Travitzky
    Ulrich Kneser
    Elias Polykandriotis
    Raymund Horch
    Peter Greil
    [J]. Journal of Materials Science: Materials in Medicine, 2008, 19 : 2781 - 2790
  • [3] Porous ceramic bone scaffolds for vascularized bone tissue regeneration
    Will, Julia
    Melcher, Reinhold
    Treul, Cornelia
    Travitzky, Nahum
    Kneser, Ulrich
    Polykandriotis, Elias
    Horch, Raymund
    Greil, Peter
    [J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2008, 19 (08) : 2781 - 2790
  • [4] Digital light processing stereolithography of hydroxyapatite scaffolds with bone-like architecture, permeability, and mechanical properties
    Baino, Francesco
    Magnaterra, Giulia
    Fiume, Elisa
    Schiavi, Alessandro
    Tofan, Luciana-Patricia
    Schwentenwein, Martin
    Verne, Enrica
    [J]. JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 2022, 105 (03) : 1648 - 1657
  • [5] Influence of AlO content on mechanical properties of silica-based ceramic cores prepared by stereolithography
    Wen ZHENG
    JiaMin WU
    Shuang CHEN
    ChangShun WANG
    ChunLei LIU
    ShuaiBin HUA
    KangBo YU
    Jie ZHANG
    JingXian ZHANG
    YuSheng SHI
    [J]. Journal of Advanced Ceramics . , 2021, (06) - 1388
  • [6] The Sintering Behaviour and Mechanical Properties of Hydroxyapatite - Based Composites for Bone Tissue Regeneration
    Tecu, Camelia
    Antoniac, Aurora
    Goller, Gultekin
    Gok, Mustafa Guven
    Manole, Marius
    Mohan, Aurel
    Moldovan, Horatiu
    Earar, Kamel
    [J]. REVISTA DE CHIMIE, 2018, 69 (05): : 1272 - 1275
  • [7] The Sintering Behaviour and Mechanical Properties of Hydroxyapatite - Based Composites for Bone Tissue Regeneration
    Tecu, Camelia
    Antoniac, Iulian
    Goller, Gultekin
    Yavas, Baris
    Gheorghe, Dan
    Antoniac, Aurora
    Ciuca, Ion
    Semenescu, Augustin
    Raiciu, Anca Daniela
    Cristescu, Ioan
    [J]. MATERIALE PLASTICE, 2019, 56 (03) : 644 - 648
  • [8] Wollastonite/hydroxyapatite scaffolds with improved mechanical, bioactive and biodegradable properties for bone tissue engineering
    Padmanabhan, Sanosh Kunjalukkal
    Gervaso, Francesca
    Carrozzo, Marina
    Scalera, Francesca
    Sannino, Alessandro
    Licciulli, Antonio
    [J]. CERAMICS INTERNATIONAL, 2013, 39 (01) : 619 - 627
  • [9] Effects of compressive ratio and sintering temperature on mechanical properties of biocompatible collagen/hydroxyapatite composite scaffolds fabricated for bone tissue engineering
    Islam, Md Shariful
    Rahman, A. M. Zahidur
    Sharif, M. H.
    Khan, Alam
    Abdulla-Al-Mamu, Md
    Todo, Mitsugu
    [J]. JOURNAL OF ASIAN CERAMIC SOCIETIES, 2019, 7 (02) : 183 - 198
  • [10] The influence of micropore size on the mechanical properties of bulk hydroxyapatite and hydroxyapatite scaffolds
    Cordell, Jacqueline M.
    Vogl, Michelle L.
    Johnson, Amy J. Wagoner
    [J]. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 2009, 2 (05) : 560 - 570
12345