AVPCD: a plant-derived medicine database of antiviral phytochemicals for cancer, Covid-19, malaria and HIV

被引:6
|
作者
Ullah, Shahid [1 ]
Rahman, Wajeeha [1 ]
Ullah, Farhan [1 ]
Ullah, Anees [1 ]
Ahmad, Gulzar [1 ]
Ijaz, Muhammad [1 ]
Ullah, Hameed [1 ]
Zheng, Zilong [2 ]
Gao, Tianshun [2 ]
机构
[1] S Khan Lab Mardan, Takhtbhai 23200, KP, Pakistan
[2] Sun Yat Sen Univ, Affiliated Hosp 7, Big Data Ctr, Shenzhen 518107, Peoples R China
关键词
BIFLAVONOID INHIBITOR; ACID-DERIVATIVES; MORELLOFLAVONE;
D O I
10.1093/database/baad056
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Serious illnesses caused by viruses are becoming the world's most critical public health issues and lead millions of deaths each year in the world. Thousands of studies confirmed that the plant-derived medicines could play positive therapeutic effects on the patients with viral diseases. Since thousands of antiviral phytochemicals have been identified as lifesaving drugs in medical research, a comprehensive database is highly desirable to integrate the medicinal plants with their different medicinal properties. Therefore, we provided a friendly antiviral phytochemical database AVPCD covering 2537 antiviral phytochemicals from 383 medicinal compounds and 319 different families with annotation of their scientific, family and common names, along with the parts used, disease information, active compounds, links of relevant articles for COVID-19, cancer, HIV and malaria. Furthermore, each compound in AVPCD was annotated with its 2D and 3D structure, molecular formula, molecular weight, isomeric SMILES, InChI, InChI Key and IUPAC name and 21 other properties. Each compound was annotated with more than 20 properties. Specifically, a scoring method was designed to measure the confidence of each phytochemical for the viral diseases. In addition, we constructed a user-friendly platform with several powerful modules for searching and browsing the details of all phytochemicals. We believe this database will facilitate global researchers, drug developers and health practitioners in obtaining useful information against viral diseases.
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页数:10
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