Prognostic Parameters of Palbociclib in HR+/HER2-Advanced Breast Cancer: A Narrative Review

被引：0

作者：

Wang, Wei ^{[1
,2
]}

Wu, Jiayi ^{[1
,3
]}

Chen, Keyu ^{[1
,3
]}

Wang, Xiaojia ^{[1
]}

Shao, Xiying ^{[1
]}

机构：

[1] Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Med Oncol,Breast Canc, 1 Banshandong Rd, Hangzhou, Peoples R China

[2] Wenzhou Med Univ, Dept Clin Med, Wenzhou, Peoples R China

[3] Zhejiang Chinese Med Univ, Dept Clin Med, Hangzhou, Peoples R China

来源：

TECHNOLOGY IN CANCER RESEARCH & TREATMENT | 2023年 / 22卷

关键词：

breast cancer; palbociclib; CDK4; 6; inhibitor; prognostic parameters; LETROZOLE;

D O I：

10.1177/15330338231173504

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent studies have demonstrated that the combination of Cyclin-Dependent Kinase 4/6 Inhibitor (CDK4/6i) and endocrine therapy (ET) is more effective than ET alone and significantly improves progression-free survival (PFS) and overall survival (OS) in patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor-2 negative (HER2-) breast cancer (BC). Palbociclib is the first CDK4/6i approved for use, and its clinical advantages have been shown. However, 30% of patients will continue to develop secondary drug resistance. Therefore, exploring the parameters that can predict the efficacy of Palbociclib and developing a clinical prediction model is essential for evaluating the prognosis of patients.

引用

页数：9

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