Breaking the deadlock in genetic code expansion

被引：2

作者：

Hou, Ya-Ming ^{[1
]}

Nakano, Yuko ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Biochem & Mol Biol, Philadelphia, PA 19144 USA

来源：

NATURE CHEMICAL BIOLOGY | 2024年 / 20卷 / 4期

关键词：

PEPTIDES;

D O I：

10.1038/s41589-024-01579-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reprogramming of the genetic code allows the synthesis of proteins using new building blocks, thus opening the door to the development of a wider variety of medicines and biocatalysts; however, it is currently limited to alpha-amino acids. A new study has now reported the incorporation of beta-linked and alpha,alpha-disubstituted monomers into a ribosome-synthesized protein.

引用

页码：406 / 407

页数：2

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