Seroepidemiological investigation of Crimean Congo hemorrhagic fever virus in livestock in Uganda, 2017

被引:5
|
作者
Nyakarahuka, Luke [1 ,2 ]
Kyondo, Jackson [1 ]
Telford, Carson [3 ]
Whitesell, Amy [3 ]
Tumusiime, Alex [1 ]
Mulei, Sophia [1 ]
Baluku, Jimmy [1 ]
Cossaboom, Caitlin M. [3 ]
Cannon, Deborah L. [3 ]
Montgomery, Joel M. [3 ]
Lutwama, Julius J. [1 ]
Nichol, Stuart T. [3 ]
Balinandi, Stephen K. [1 ]
Klena, John D. [3 ]
Shoemaker, Trevor R. [3 ]
机构
[1] Uganda Virus Res Inst, Dept Arbovirol Emerging & Reemerging Infect Dis, Entebbe, Uganda
[2] Makerere Univ, Coll Vet Med Anim Resources & Biosecur, Dept Biosecur Ecosyst & Vet Publ Hlth, Kampala, Uganda
[3] United States Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA USA
来源
PLOS ONE | 2023年 / 18卷 / 11期
关键词
RISK-FACTORS;
D O I
10.1371/journal.pone.0288587
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Crimean-Congo Hemorrhagic fever (CCHF) is an important zoonotic disease transmitted to humans both by tick vectors and contact with fluids from an infected animal or human. Although animals are not symptomatic when infected, they are the main source of human infection. Uganda has reported sporadic human outbreaks of CCHF in various parts of the country since 2013. We designed a nationwide epidemiological study to investigate the burden of CCHF in livestock. A total of 3181 animals were sampled; 1732 cattle (54.4%), 1091 goats (34.3%), and 358 sheep (11.3%) resulting in overall livestock seropositivity of IgG antibodies against CCHF virus (CCHFV) of 31.4% (999/3181). Seropositivity in cattle was 16.9% and in sheep and goats was 48.8%. Adult and juvenile animals had higher seropositivity compared to recently born animals, and seropositivity was higher in female animals (33.5%) compared to male animals (24.1%). Local breeds had higher (36.8%) compared to exotic (2.8%) and cross breeds (19.3%). Animals that had a history of abortion or stillbirth had higher seropositivity compared to those without a history of abortion or stillbirth. CCHFV seropositivity appeared to be generally higher in northern districts of the country, though spatial trends among sampled districts were not examined. A multivariate regression analysis using a generalized linear mixed model showed that animal species, age, sex, region, and elevation were all significantly associated with CCHFV seropositivity after adjusting for the effects of other model predictors. This study shows that CCHFV is actively circulating in Uganda, posing a serious risk for human infection. The results from this study can be used to help target surveillance efforts for early case detection in animals and limit subsequent spillover into humans.
引用
收藏
页数:13
相关论文
共 50 条
  • [1] Spatial prediction of Crimean Congo hemorrhagic fever virus seroprevalence among livestock in Uganda
    Telford, Carson
    Nyakarahuka, Luke
    Waller, Lance
    Kitron, Uriel
    Shoemaker, Trevor
    ONE HEALTH, 2023, 17
  • [2] Crimean-Congo Hemorrhagic Fever Virus in Humans and Livestock, Pakistan, 2015-2017
    Zohaib, Ali
    Saqib, Muhammad
    Athar, Muhammad A.
    Hussain, Muhammad H.
    Sial, Awais-ur-Rahman
    Tayyab, Muhammad H.
    Batool, Murrafa
    Sadia, Halima
    Taj, Zeeshan
    Tahir, Usman
    Jakhrani, Muhammad Y.
    Tayyab, Jawad
    Kakar, Muhammad A.
    Shahid, Muhammad F.
    Yaqub, Tahir
    Zhang, Jingyuan
    Wu, Qiaoli
    Deng, Fei
    Corman, Victor M.
    Shen, Shu
    Khan, Iahtasham
    Shi, Zheng-Li
    EMERGING INFECTIOUS DISEASES, 2020, 26 (04) : 773 - 777
  • [3] Seroepidemiological Investigation of Crimean-Congo Hemorrhagic Fever Virus in Sheep and Camels of Inner Mongolia of China
    Li, Yong
    Yan, Chao
    Liu, Dongxiao
    He, Biao
    Tu, Changchun
    VECTOR-BORNE AND ZOONOTIC DISEASES, 2020, 20 (06) : 461 - 467
  • [4] Seroepidemiological Studies of Crimean-Congo Hemorrhagic Fever Virus in Domestic and Wild Animals
    Spengler, Jessica R.
    Bergeron, Eric
    Rollin, Pierre E.
    PLOS NEGLECTED TROPICAL DISEASES, 2016, 10 (01):
  • [5] Longitudinal seroprevalence of Crimean-Congo hemorrhagic fever virus in Southern Uganda
    Mihalakakos, Evan A.
    Ssempijja, Victor
    Ribeiro, Ruy M.
    Molina-Paris, Carmen
    Katushabe, Gerald
    Nalwadda, Josephine
    Omooja, Jonah
    Byarugaba, Denis K.
    Rosenke, Kyle
    Reynolds, Steven J.
    Grabowski, Mary K.
    Galiwango, Ronald M.
    Ssekubugu, Robert
    Feldmann, Heinz
    Hawman, David W.
    EMERGING MICROBES & INFECTIONS, 2025, 14 (01)
  • [6] Serosurvey of Crimean-Congo hemorrhagic fever virus in livestock, Kohgiluyeh and Boyer-Ahmad, Iran, 2017
    Ghasemian, Sayedeh Ommolbanin
    Fazlalipour, Mehdi
    Hosseini, Ghasem
    Pouryaievali, Mohammad Hassan
    Azad-Manjiri, Sanam
    Khakifirouz, Sahar
    Vasmehjani, Abbas Ahmadi
    Salehi-Vaziri, Mostafa
    JOURNAL OF VECTOR BORNE DISEASES, 2021, 58 (01) : 70 - 73
  • [7] Prevalence of Crimean-Congo Hemorrhagic Fever Virus among Livestock and Ticks in Zhambyl Region, Kazakhstan, 2017
    Bryant-Genevier, Jonathan
    Bumburidi, Yekaterina
    Kazazian, Lilit
    Seffren, Victoria
    Head, Jennifer R.
    Berezovskiy, Dmitriy
    Zhakipbayeva, Bakhytkul
    Salyer, Stephanie J.
    Knust, Barbara
    Klena, John D.
    Chiang, Cheng-Feng
    Mirzabekova, Gulfaira
    Rakhimov, Kumisbek
    Koekeev, Jandar
    Kartabayev, Kanatbek
    Mamadaliyev, Seydigapbar
    Guerra, Marta
    Blanton, Curtis
    Shoemaker, Trevor
    Singer, Daniel
    Moffett, Daphne B.
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2022, 106 (05): : 1478 - 1485
  • [8] RESULTS OF A PRELIMINARY SEROEPIDEMIOLOGICAL SURVEY FOR CRIMEAN-CONGO HEMORRHAGIC-FEVER VIRUS IN EGYPT
    DARWISH, MA
    IMAM, IZE
    OMAR, FM
    HOOGSTRAAL, H
    ACTA VIROLOGICA, 1978, 22 (01) : 77 - 77
  • [9] CONGO-CRIMEAN HEMORRHAGIC-FEVER IN IRAQ - A SEROEPIDEMIOLOGICAL SURVEY
    ALTIKRITI, SK
    HASSAN, FK
    MOSLIH, IM
    JURJI, F
    MAHMUD, MIA
    TANTAWI, HH
    JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1981, 84 (03): : 117 - 120
  • [10] Phylogeography of Crimean Congo Hemorrhagic Fever Virus
    Lukashev, Alexander N.
    Klimentov, Alexander S.
    Smirnova, Svetlana E.
    Dzagurova, Tamara K.
    Drexler, Jan Felix
    Gmyl, Anatoly P.
    PLOS ONE, 2016, 11 (11):