Childhood Obesity, Diabetes, and Cardiovascular Disease Risk

被引：8

作者：

Salama, Mostafa ^{[1
,2
]}

Balagopal, Babu ^{[2
,3
]}

Fennoy, Ilene ^{[4
]}

Kumar, Seema ^{[1
,2
]}

机构：

[1] Mayo Clin, Div Pediat Endocrinol & Metab, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Pediat, Rochester, MN 55905 USA

[3] Nemours Childrens Hlth Syst, Dept Biomed Res, Jacksonville, FL 32207 USA

[4] Columbia Univ, Div Pediat Endocrinol Diabet & Metab, New York, NY 10032 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2023年 / 108卷 / 12期

关键词：

childhood obesity; cardiovascular; diabetes; pathophysiology; treatment; BODY-MASS INDEX; GLUCAGON-LIKE PEPTIDE-1; ENDOPLASMIC-RETICULUM STRESS; FAMILY-BASED TREATMENT; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; SCIENTIFIC STATEMENT; GAMMA' FIBRINOGEN; WEIGHT-GAIN;

D O I：

10.1210/clinem/dgad361

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This mini-review aims to briefly summarize the pathophysiology of childhood obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD) risk in children and adolescents. Recent data on efficacy of lifestyle interventions, medications, and metabolic surgery for obesity, T2DM, and CVD risk factors are also reviewed. We conducted a PubMed search of English-language original and review articles relevant to childhood obesity, T2DM, and CVD risk factors, and biomarkers in children with an emphasis on recent publications. Childhood obesity arises from an intricate interaction between genetic, physiologic, environmental, and socioeconomic factors. The rise in the prevalence of childhood obesity is associated with the development of comorbidities including T2DM and CVD at an early age. A multipronged approach is central to the detection, monitoring, and management of childhood obesity and associated adverse metabolic consequences.

引用

页码：3051 / 3066

页数：16

共 50 条

[1] Childhood Obesity and Cardiovascular Disease Risk
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[J]. CURRENT ATHEROSCLEROSIS REPORTS, 2023, 25 (07) : 405 - 415
[2] Childhood Obesity and Cardiovascular Disease Risk
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[J]. Current Atherosclerosis Reports, 2023, 25 : 405 - 415
[3] Childhood Obesity, Diabetes, and Cardiovascular Disease Risk (vol 108, pg 3051, 2023)
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[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2024, 109 (05): : e1422 - e1422
[4] Obesity and the risk of cardiovascular disease and diabetes mellitus
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[10] Childhood obesity and adult cardiovascular disease risk: a systematic review
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