Maternal Hypertension and Early-Onset Neonatal Neutropenia

被引：0

作者：

Joslyn, Peter ^{[1
,3
]}

Oral, Evrim ^{[2
]}

Martin, Anne ^{[1
]}

Surcouf, Jeffrey ^{[1
]}

Barkemeyer, Brian ^{[1
]}

机构：

[1] Louisiana State Univ, Dept Pediat, Hlth Sci Ctr New Orleans, New Orleans, LA USA

[2] Louisiana State Univ, Sch Publ Hlth, Biostat Program, Hlth Sci Ctr New Orleans, New Orleans, LA USA

[3] Louisiana State Univ, Dept Pediat, Div Neonatol, Hlth Sci Ctr New Orleans, 200 Henry Clay Ave, New Orleans, LA 70118 USA

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2023年 / 42卷 / 05期

关键词：

Preeclampsia; hypertension; neutropenia; neonate; very low birthweight infants; NOSOCOMIAL INFECTION; WEIGHT; BIRTH; COUNT; BLOOD; RISK; MANIFESTATIONS; INFANTS; SEPSIS; HEALTH;

D O I：

10.1080/15513815.2023.2220406

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objective: Maternal hypertension is considered a risk factor for early neonatal neutropenia. We sought to explore this relationship. Study Design: This retrospective cohort study compared initial neutrophil counts in infants born to mothers with preeclampsia with severe features (PSF) and infants born to normotensive mothers using Negative Binomial Regression (NBR) and logistic regression models. Results: Maternal hypertension negatively affected the early neonatal neutrophil count (adjusted NRB coefficient 0.4 [0.2, 0.6], p < 0.0001) but did not increase the risk of neutropenia (OR 2.07 [0.97, 4.41], p = 0.06). The initial neutrophil count and neutropenia risk were not different between PSF subgroups. Gestational age had the greatest impact on neutropenia risk (OR 0.72 [0.64, 0.81], p < 0.0001). Almost all neutropenia resolved within 48 h. Conclusion: Maternal hypertension negatively affects the early neonatal neutrophil count while not increasing the risk of neonatal neutropenia.

引用

页码：735 / 745

页数：11

共 50 条

[1] MATERNAL HYPERTENSION AND NEONATAL NEUTROPENIA
OSHEA, TM
BLOCK, SM
DILLARD, RG
BERRY, DD
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (06): : 405 - 405
[2] THE NEONATAL NEUTROPENIA ASSOCIATED WITH MATERNAL HYPERTENSION
KOENIG, JM
CHRISTENSEN, RD
[J]. PEDIATRIC RESEARCH, 1989, 25 (04) : A221 - A221
[3] Implementation of the Neonatal Sepsis Calculator in Early-Onset Sepsis and Maternal Chorioamnionitis
Akangire, Gangaram
Simpson, Elizabeth
Weiner, Julie
Noel-MacDonnell, Janelle
Petrikin, Joshua
Sheehan, Michael
[J]. ADVANCES IN NEONATAL CARE, 2020, 20 (01) : 25 - 32
[4] Early-onset neonatal hyperkalemia associated with maternal hypermagnesemia: a case report
Kenichi Tanaka
Hiroko Mori
Rieko Sakamoto
Shirou Matsumoto
Hiroshi Mitsubuchi
Kimitoshi Nakamura
Masanori Iwai
[J]. BMC Pediatrics, 18
[5] Maternal pneumococcal endometritis may cause early-onset neonatal sepsis
Pace, Julio
Bonofiglio, Laura
Lopez Moral, Laura
Badia, Marcela
Lachener, Debora
Regueira, Mabel
Mollerach, Marta
[J]. JOURNAL OF PEDIATRIC INFECTIOUS DISEASES, 2007, 2 (04) : 241 - 245
[6] Early-onset neonatal hyperkalemia associated with maternal hypermagnesemia: a case report
Tanaka, Kenichi
Mori, Hiroko
Sakamoto, Rieko
Matsumoto, Shirou
Mitsubuchi, Hiroshi
Nakamura, Kimitoshi
Iwai, Masanori
[J]. BMC PEDIATRICS, 2018, 18
[7] Early-Onset Neonatal Sepsis
Solevag, Anne Lee
Saugstad, Ola Didrik
[J]. JOURNAL OF PEDIATRICS, 2021, 238 : 32 - +
[8] Early-Onset Neonatal Sepsis
Simonsen, Kari A.
Anderson-Berry, Ann L.
Delair, Shirley F.
Davies, H. Dele
[J]. CLINICAL MICROBIOLOGY REVIEWS, 2014, 27 (01) : 21 - 47
[9] Neonatal neutropenia and thrombocytopenia following maternal hypertension
Fraser, SH
Tudehope, DI
[J]. JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 1996, 32 (01) : 31 - 34
[10] Dynamics and incidence patterns of maternal complications in early-onset hypertension of pregnancy
Ganzevoort, W.
Rep, A.
Bonsel, G. J.
de Vries, J. I. P.
Wolf, H.
[J]. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2007, 114 (06) : 741 - 750

← 1 2 3 4 5 →