DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-Phenanthroline

被引：0

作者：

Kasyanenko, Nina ^{[1
]}

Belyi, Eugeny ^{[1
]}

Silanteva, Irina ^{[1
]}

Demidov, Victor ^{[2
]}

Komolkin, Andrei ^{[1
]}

机构：

[1] St Petersburg State Univ, Fac Phys, St Petersburg 199034, Russia

[2] Russian Acad Sci, IV Grebenshchikov Inst Silicate Chem, St Petersburg 194021, Russia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 03期

关键词：

Cd(II) compounds; 1,10-phenanthroline ligands; DNA binding; intercalation; molecular dynamics; MOLECULAR-DYNAMICS; COMPLEXES; PHENANTHROLINE; BINDING;

D O I：

10.3390/ijms25031820

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The experimental study of the DNA interaction with three cadmium coordination compounds [Cd(phen)3](CH3CO2)2, [Cd(phen)2(H2O)2](CH3CO2)2, and [Cd2(phen)4(H2O)2](CH3CO2)4 was carried out using spectrophotometry, viscosity, and dynamic light scattering methods. The role of the solution ionic strength (concentration of NaCl) was analyzed. All compounds can penetrate (fully or partly) to the major or minor DNA grooves. It was shown that, in addition to the important role of electrostatic interactions in the formation of the complex, intercalation of the 1,10-phenanthroline ligand occurs for compounds [Cd(phen)2(H2O)2](CH3CO2)2 and [Cd2(phen)4(H2O)2](CH3CO2)4. Compound [Cd(phen)3](CH3CO2)2 binds to DNA externally. The coordination bond between cadmium and DNA was formed in DNA complexes with [Cd2(phen)4(H2O)2](CH3CO2)4. Preliminary computer modeling of the DNA interaction with the compounds used was performed.

引用

页数：17

共 50 条

[1] Coordination cadmium compounds with 1,10-phenanthroline
Zhang, WG
Jiang, XH
Zhong, Y
Tan, MY
Wang, SL
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 2002, 67 (11) : 1623 - 1628
[2] POLAROGRAPHY OF SOME COORDINATION COMPOUNDS OF PLATINUM .4. COMPOUNDS OF PLATINUM(II) CONTAINING 1,10-PHENANTHROLINE
HALL, JR
PLOWMAN, RA
AUSTRALIAN JOURNAL OF CHEMISTRY, 1956, 9 (02) : 143 - 150
[3] DNA interaction of platinum(II) complexes with 1,10-phenanthroline and extended phenanthrolines
Cusumano, M
Di Pietro, ML
Giannetto, A
INORGANIC CHEMISTRY, 2006, 45 (01) : 230 - 235
[4] DNA Interaction Studies of a Platinum(II) Complex Containing L-Histidine and 1,10-Phenanthroline Ligands
Shahabadi, Nahid
Nemati, Leila
DNA AND CELL BIOLOGY, 2012, 31 (05) : 883 - 890
[5] DNA binding of iron(II) mixed-ligand complexes containing 1,10-phenanthroline and 4,7-diphenyl-1,10-phenanthroline
Mudasir
Yoshioka, N
Inoue, H
JOURNAL OF INORGANIC BIOCHEMISTRY, 1999, 77 (3-4) : 239 - 247
[6] Outer-sphere coordination of 1,10-phenanthroline in bis(aquatrifluoroacetatotriphenyltin-1,10-phenanthroline)
Ng, SW
Das, VGK
Kennard, CHL
MAIN GROUP METAL CHEMISTRY, 1996, 19 (02): : 107 - 111
[7] Vibronic spectra of europium compounds containing derivatives of 1,10-phenanthroline
Tsaryuk, V
Zolin, V
Legendziewicz, J
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 1998, 54 (13) : 2247 - 2254
[8] Synthesis and Crystal Structure of a New Cd(II) Coordination Polymer Based on a 1,10-Phenanthroline Derivative
Xu, Zhan-Lin
Ma, Shuai
He, Yu
Kong, Zhi-Guo
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2011, 66 (05): : 538 - 540
[9] Three new lanthanide coordination polymers containing isophthalate and 1,10-phenanthroline
Wan, YH
Zhang, LP
Jin, LP
JOURNAL OF MOLECULAR STRUCTURE, 2003, 658 (03) : 253 - 260
[10] Iron(II) and nickel(II) mixed-ligand complexes containing 1,10-phenanthroline and 4,7-diphenyl-1,10-phenanthroline
Mudasir
Yoshioka N.
Inoue H.
Transition Metal Chemistry, 1999, 24 (2) : 210 - 217

← 1 2 3 4 5 →