The inhaled PDE4 inhibitor tanimilast shows efficacy in both Th2 and non-Th2 murine models of asthma

被引:1
|
作者
Pisano, Rita [1 ]
Fragni, Debora [1 ]
Allen, Andrew [1 ]
Tondelli, Marina [1 ]
Pappani, Alice [1 ]
De Angelis, Davide [1 ]
Civelli, Maurizio [1 ]
Villetti, Gino [1 ]
Miglietta, Daniela [1 ]
机构
[1] Chiesi Farmaceutici SpA, Parma, PR, Italy
关键词
Asthma. Pharmacology. Animal models;
D O I
10.1183/13993003.congress-2023.OA4305
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Tanimilast, A Novel Inhaled Pde4 Inhibitor for the Treatment of Asthma and Chronic Obstructive Pulmonary Disease
    Facchinetti, Fabrizio
    Civelli, Maurizio
    Singh, Dave
    Papi, Alberto
    Emirova, Aida
    Govoni, Mirco
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [2] Mixed Th2 and non-Th2 inflammatory pattern in the asthma-COPD overlap: a network approach
    Perez de Llano, Luis
    Cosio, Borja G.
    Iglesias, Amanda
    de las Cuevas, Natividad
    Jose Soler-Cataluna, Juan
    Luis Izquierdo, Jose
    Luis Lopez-Campos, Jose
    Calero, Carmen
    Plaza, Vicente
    Miravitlles, Marc
    Torrego, Alfons
    Martinez-Moragon, Eva
    Soriano, Joan B.
    Lopez Vina, Antolin
    Bobolea, Irina
    INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2018, 13 : 591 - 601
  • [3] Obesity Enhances Non-Th2 Airway Inflammation in a Murine Model of Allergic Asthma
    Mohamed, Marwa M. E.
    Amrani, Yassine
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (11)
  • [4] The PDE4 inhibitor tanimilast shows distinct immunomodulatory properties associated with a type 2 endotype and CD141 upregulation
    Nguyen, H. O.
    Salvi, V.
    Tiberio, L.
    Govoni, M.
    Villetti, G.
    Civelli, M.
    Barbazza, I.
    Gaudenzi, C.
    Passari, M.
    Schioppa, T.
    Sozio, F.
    Dal Prete, A.
    Sozzani, S.
    Bosisio, D.
    Facchinetti, F.
    EUROPEAN RESPIRATORY JOURNAL, 2022, 60
  • [5] The PDE4 inhibitor tanimilast shows distinct immunomodulatory properties associated with a type 2 endotype and CD141 upregulation
    Nguyen, Hoang Oanh
    Salvi, Valentina
    Tiberio, Laura
    Facchinetti, Fabrizio
    Govoni, Mirco
    Villetti, Gino
    Civelli, Maurizio
    Barbazza, Ilaria
    Gaudenzi, Carolina
    Passari, Mauro
    Schioppa, Tiziana
    Sozio, Francesca
    Del Prete, Annalisa
    Sozzani, Silvano
    Bosisio, Daniela
    JOURNAL OF TRANSLATIONAL MEDICINE, 2022, 20 (01)
  • [6] ADEPT-derived, U-BIOPRED validated asthma clinical clusters with Th2 and non-Th2 phenotypes
    Loza, Matthew
    Silkoff, Philip
    Susilic, Vedrana
    Rowe, Anthony
    Adcock, Ian
    Auffray, Charles
    Chung, Klan Fan
    Djukanovic, Ratko
    Sterk, Peter
    Baribaud, Frederic
    EUROPEAN RESPIRATORY JOURNAL, 2014, 44
  • [7] The PDE4 inhibitor tanimilast shows distinct immunomodulatory properties associated with a type 2 endotype and CD141 upregulation
    Hoang Oanh Nguyen
    Valentina Salvi
    Laura Tiberio
    Fabrizio Facchinetti
    Mirco Govoni
    Gino Villetti
    Maurizio Civelli
    Ilaria Barbazza
    Carolina Gaudenzi
    Mauro Passari
    Tiziana Schioppa
    Francesca Sozio
    Annalisa Del Prete
    Silvano Sozzani
    Daniela Bosisio
    Journal of Translational Medicine, 20
  • [8] Innate players in Th2 and non-Th2 asthma: emerging roles for the epithelial cell, mast cell, and monocyte/macrophage network
    Kotrba, Johanna
    Mueller, Ilka
    Pausder, Alexander
    Hoffmann, Aaron
    Camp, Belinda
    Boehme, Julia D.
    Mueller, Andreas J.
    Schreiber, Jens
    Bruder, Dunja
    Kahlfuss, Sascha
    Dudeck, Anne
    Stegemann-Koniszewski, Sabine
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2024, 327 (06): : C1373 - C1383
  • [9] T-helper cell type 2 (Th2) and non-Th2 molecular phenotypes of asthma using sputum transcriptomics in U-BIOPRED
    Kuo, Chih-Hsi Scott
    Pavlidis, Stelios
    Loza, Matthew
    Baribaud, Fred
    Rowe, Anthony
    Pandis, Iaonnis
    Sousa, Ana
    Corfield, Julie
    Djukanovic, Ratko
    Lutter, Rene
    Sterk, Peter J.
    Auffray, Charles
    Guo, Yike
    Adcock, Ian M.
    Chung, Kian Fan
    EUROPEAN RESPIRATORY JOURNAL, 2017, 49 (02)
  • [10] The PDE4 Inhibitor Tanimilast Blunts Proinflammatory Dendritic Cell Activation by SARS-CoV-2 ssRNAs
    Nguyen, Hoang Oanh
    Schioppa, Tiziana
    Tiberio, Laura
    Facchinetti, Fabrizio
    Villetti, Gino
    Civelli, Maurizio
    Del Prete, Annalisa
    Sozio, Francesca
    Gaudenzi, Carolina
    Passari, Mauro
    Barbazza, Ilaria
    Sozzani, Silvano
    Salvi, Valentina
    Bosisio, Daniela
    FRONTIERS IN IMMUNOLOGY, 2022, 12