Lifting the curtain on loop extrusion barriers: Single-molecule insights into cohesin stalling

被引：0

作者：

Braccioli, Luca ^{[1
]}

de Wit, Elzo ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Gene Regulat, Amsterdam, Netherlands

来源：

MOLECULAR CELL | 2023年 / 83卷 / 16期

基金：

欧洲研究理事会;

关键词：

D O I：

10.1016/j.molcel.2023.07.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this issue, Zhang et al.1 show that CTCF blocks cohesin-mediated loop extrusion in an orientation -dependent manner. Using single-molecule imaging assays, the authors find that dCas9 and R-loops can also stall extrusion.

引用

页码：2834 / 2836

页数：3

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