Quantitative 3D Temperature Rendering of Deep Tumors by a NIR-II Reversibly Responsive W-VO2@PEG Photoacoustic Nanothermometer to Promote Precise Cancer Photothermal Therapy

被引：10

作者：

Sun, Ting ^{[1
,2
]}

Zhang, Zhenhui ^{[1
,2
]}

Cui, Dandan ^{[1
,2
]}

Mu, Gen ^{[1
,2
]}

Sun, Xiaodong ^{[1
,2
]}

Su, Xiaoye ^{[1
,2
]}

Shi, Yujiao ^{[1
,2
]}

机构：

[1] South China Normal Univ, MOE Key Lab Laser Life Sci & Inst Laser Life Sci, Coll Biophoton, Guangzhou 510631, Peoples R China

[2] South China Normal Univ, Coll Biophoton, Guangdong Prov Key Lab Laser Life Sci, Guangzhou 510631, Peoples R China

来源：

ACS NANO | 2023年 / 17卷 / 15期

基金：

中国国家自然科学基金;

关键词：

quantitative temperature-rendering; photothermal therapy; reversibly responsive; NIR-II; photoacousticnanothermometer; TRANSITION TEMPERATURE; OPTICAL-PROPERTIES; VO2; WINDOW; MANIPULATION; MODULATION; MICROSCOPY; FILM;

D O I：

10.1021/acsnano.3c01723

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Accurately monitoring the three-dimensional (3D) temperaturedistributionof the tumor area in situ is a critical task thatremains challenging in precision cancer photothermal (PT) therapy.Here, by ingeniously constructing a polyethylene glycol-coated tungsten-dopedvanadium dioxide (W-VO2@PEG) photoacoustic (PA) nanothermometer(NThem) that linearly and reversibly responds to the thermal fieldnear the human-body-temperature range, the authors propose a methodto realize quantitative 3D temperature rendering of deep tumors topromote precise cancer PT therapy. The prepared NThems exhibit amild phase transition from the monoclinic phase to the rutile phasewhen their temperature grows from 35 to 45 degrees C, with the opticalabsorption sharply increased similar to 2-fold at 1064 nm in an approximatelylinear manner in the near-infrared-II (NIR-II) region, enabling W-VO2@PEG to be used as NThems for quantitative temperature monitoringof deep tumors with basepoint calibration, as well as diagnostic agentsfor PT therapy. Experimental results showed that the temperature measurementaccuracy of the proposed method can reach 0.3 degrees C, with imagingdepths up to 2 and 0.65 cm in tissue-mimicking phantoms and mousetumor tissue, respectively. In addition, it was verified through PTtherapy experiments in mice that the proposed method can achieve extremelyhigh PT therapy efficiency by monitoring the temperature of the targetarea during PT therapy. This work provides a potential demonstrationpromoting precise cancer PT therapy through quantitative 3D temperaturerendering of deep tumors by PA NThems with higher security and higherefficacy.

引用

页码：14604 / 14618

页数：15